hemosiderosis

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hemosiderosis

[‚hē·mō‚sid·ə′rō·səs]
(physiology)
Deposition of hemosiderin in body tissues without tissue damage, reflecting an increase in body iron stores.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
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I am sure that continued work will help to clarify the genetics of hepatic and systemic iron overload, and I hope that such work will help to explain the finding of hepatic hemosiderosis in patients with liver disease but without the C282Y mutation.
All patients were categorized into four groups based on their T2*MRI milliseconds (ms) results according to following cutoff points; cardiac hemosiderosis: normal > 20 ms, mild: 14-20 ms, moderate: 10-14 ms, severe < 10 ms; hepatic hemosiderosis: normal > 6.3 ms, mild: 2.8-6.3 ms, moderate: 1.4-2.7 ms, severe < 1.4 ms; LIC: normal > 2 ms, mild: 2-5 ms, moderate: 5-10 ms, severe > 10 ms.
The comparison of BTM patients with and without hemosiderosis revealed that plasma ferritin levels, iron levels, and transferrin saturation index were significantly higher in BTM patients with hepatic hemosiderosis than those without hepatic hemosiderosis (p = 0.021; p = 0.001; p = 0.010, respectively).
The patient's chemotherapeutic drugs included known hepatotoxins, but her total methotrexate dose was only 450 mg, and the drug combinations in question are commonly received without leading to hepatic cirrhosis or hepatic hemosiderosis.