These foreign bodies created multiple problems: possible heavy metal toxicosis, perforation of the gastrointestinal tract, coelomitis, hepatic necrosis
, sepsis, and ultimately death of the bird.
Pathological evaluations awaiting publication have revealed that acetaminophen-induced hepatic necrosis
is not uniformly distributed throughout the liver.
Microscopic sections showed massive hepatic necrosis
with collapse and minimal fibrosis predominantly in Rappaport zones 2 and 3 (Figure 2).
In the work with hepatic necrosis
patients, I found alpha lipoic acid to be so effective in treating acute liver disease that I decided to explore its use for chronic conditions such as hepatitis C.
NYU School of Medicine researchers found an abundance of dendritic cells in the liver can protect the organ from acetaminophen damage while low levels of dendritic cells in the liver are associated with exacerbated liver damage, liver cell and tissue death, known as centrilobular hepatic necrosis
, and acute liver failure from acetaminophen.
The dose-related increase in acute lymphoid hepatic necrosis
was observed in 10 of 48 carprofen-treated pigeons (21%), all of which had hepatic lipidosis.
In addition, ballooning, cloudy swelling, hydropic degeneration and hepatic necrosis
were the most predominant lesions.
Patients may develop severe dehydration, electrolyte disturbances, and increased liver function biomarkers [alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LD); alkaline phosphatase] heralding the onset of hepatic necrosis
It used to be that propylthiouracil (PTU) or methimazole could be used interchangeably, but there's now good evidence that there's a very serious hepatic necrosis
associated with PTU; it's rare, but it's not at all associated with methimazole," she said.
4] are conventional markers of liver injury leading to centrilobular hepatic necrosis
(Lynch et al.
These toxic metabolites may cause fetal hepatic necrosis
The outcome of hepatic artery thrombosis is variable, and may range from elevated liver enzymes to biliary stricture and necrosis to fulminant hepatic necrosis
and loss of the graft.