hepatotoxin

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hepatotoxin

[¦hep·əd·ō′täk·sən]

(pharmacology)

An agent capable of damaging the liver.

References in periodicals archive ?

This finding is of particular relevance, since orally ingested N-oxides of PAs have similar hepatotoxic properties as their parent alkaloids, following their reduction to the corresponding free base in the human intestine (Wiedenfeld 2011; Mattocks 1986).

Detection of pyrrolizidine alkaloids in German licensed herbal medicinal teas

However, in the SA setting, HIV/TB co-infected patients with DILI often have significant immune suppression and large mycobacterial loads, and the clinician may initiate a TB treatment backbone that excludes the first-line hepatotoxic drugs while the LFTs settle and until the patient is ready for rechallenge.

Consensus statement: management of drug-induced liver injury in HIV-positive patients treated for TB

Such findings are common to acute hepatotoxic compounds (6,19).

Intoxicacion accidental de un toro con Wedelia glauca ("sunchillo") confirmada por analisis de contenido ruminal

Flavokawain B, the hepatotoxic constituent from kava root, induces GSH-sensitive oxidative stress through modulation of IKK/NF-kappaB and MAPK signaling pathways.

Effect of an acute dose of crude kava root extract on problem solving in healthy young adults

The results of the present study suggest that the hepatotoxic effects of these drugs can be largely prevented by coadministration of NAC.

Literature review & Commentary

Study design: The site of TB, method of establishing the diagnosis of TB, history of chronic liver disease, history of concomitant intake of other hepatotoxic drugs and alcohol intake were recorded.

Evaluation of risk factors for antituberculosis treatment induced hepatotoxicity

Among the topics are the design of toxicity studies of inhaled nanomedicines, biological properties of red elemental selenium at nano size in vitro and in vivo, the hepatotoxic potential of nanomaterials, in vivo hypersensitive pulmonary disease models for nanotoxicity, the incidence and mechanisms of iron oxide nanoparticle toxicity, and the safety assessment of engineered nanomaterials in direct food additives and food contact materials.

Nanotoxicity; from in vivo and in vitro models to health risks

Taken at recommended doses, naltrexone does not appear to be hepatotoxic, but it is contraindicated in patients with cirrhosis, as well as those receiving or dependent on opioids.

Not the standard sales pitch: Alkermes draws from the passion of recovery to bring its alcohol medication into treatment programs

450] isenozymes which leads to elevation of the plasma concentrations of other hepatotoxic medications (10).

No elevation of glutathione S-transferase-A1-1 by amiodarone loading in intensive care unit patients with atrial fibrillation

The mechanisms of cyanobacterial toxicity are diverse, ranging from hepatotoxic and neurotoxic effects to the inhibition of protein synthesis.

Toxins and other bioactive compounds produced by cyanobacteria in Lake Ladoga/tsuanobakterite poolt produtseeritavate toksiinide ja muude bioloogiliselt aktiivsete uhendite mitmekesisus Laadoga jarves

Clinical studies with up to four years follow-up have not disclosed any hepatotoxic effects of the drug in patients treated with this phosphate binder.

Lanthanum carbonate

Most common side effect is GI upset Zingiber officinale (ginger root) Used for its purported stimulant and antiemetic properties Rubus idaeus (red raspberry leaf) Phytoestrogens bind to estrogen receptors Valeriana officinalis (Valeriana root) Noted to be hepatotoxic, it has been used for its purported sleep aid benefit