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An alternative would be to construct a maximal orthogonal set from the set of all natural tetraheptads (coiled-coils where each of the 4 heptads occurs naturally).
Comparison of functional domain of F protein with consensus sequences identified several amino acid substitutions in signal peptide with a single substitution, total of four substitutions in heptad repeat regions (HRa,HRb,HRc) and transmembrane domain had four substitutions.
To describe the foundation of the dimerization stability and speculate the dimerization specificity of 50 FvbZIP members, we named special amino acid residue positions as g, a, b, c, d, e, and f to put in order of each heptad on the basis of standard nomenclature for the seven heptad repeats  (see Supplementary Figure S4 available online at https://doi.org/10.1155/2017/3981031).
PCR sequencing with primers Zot F/ctxA R indicated the presence of 4 heptad (TTTTGAT) repeats in the ToxR binding region of ctxAB promoter, similar to El Tor biotype (2).
MFN2 contains an N-terminal heptad repeat region (HR1) that is required to interact with the C-terminus of MARCH5.
(3.) Robert Gordis, "The Heptad as an Element of Biblical and Rabbinic Style," Journal of Biblical Literature, 62:1 (March 1943) pp.
Therefore, CHR (C-terminal Heptad Repeat) and NHR (N-terminal Heptad Repeat) join together and consequently a 6-Helix Bundle (6HB) is formed (7).
Two hydrophobic heptad repeat domains (HR) are localized in the middle (HR1) and Cterminal (HR2) regions and provide the basis for most coiledcoil interactions (Figure 1(b)).
The sequence of clone 40 was localized in the gp41 C-terminal heptad repeat.
Pvmsp-3[alpha] is characterized by a distinct block of alanine-rich heptad repeats in the central region that are predicted to form an intramolecular coiled-coil, and is polymorphic in nature.
Key Words: HIV; Heptad repeat (HR) regions; Characterization; Diagnosis; AIDS
See other essays in this collection for the history and bibliography about the heptad. On the genres of mendicant preaching aids, including model sermons, texts on the vices and virtues, and their publication, see David L.
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