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Leber's hereditary optic neuropathy (LHON) is a heritable genetic disease causing blindness.
The report provides a snapshot of the global therapeutic landscape of Leber's Hereditary Optic Neuropathy (LHON) (Leber optic atrophy)
Occurrence of a multiple sclerosis-like illness in women who have a Leber's hereditary optic neuropathy mitochondrial DNA mutation," Brain, vol.
Pedigree analysis in Leber hereditary optic neuropathy families with a pathogenic mtDNA mutation.
2003) The epidemiology of Leber hereditary optic neuropathy in the North East of England.
Santhera develops Catena/Raxone as treatment for patients with Leber's Hereditary Optic Neuropathy, Duchenne Muscular Dystrophy and Primary Progressive Multiple Sclerosis.
They include muscle-wasting mitochondrial myopathies, Leber's Hereditary Optic Neuropathy which leads to blindness, nerve illnesses similar to multiple sclerosis, and conditions that damage organs, including the heart.
Stuart Carroll, who, with his uncle Les McGuinness of Canley, has Lebers hereditary optic neuropathy which has left him with 1/60th of his eyesight, said: "Treatment for our condition is only in its development stages, so it could be years before we can have our operations.
CONTEXT: Leber hereditary optic neuropathy (LHON) is a maternally inherited loss of central vision related to pathogenic mutations in the mitochondrial genome, which are a necessary but not sufficient condition to develop the disease.
16) In that same year, specific human diseases (Leber hereditary optic neuropathy [LHON], mitochondrial myopathy, and Kearns-Sayre syndrome) were first linked to mtDNA mutation.
The first two diseases shown to have mutations in mitochondrial genes included Leber's hereditary optic neuropathy (LHON), a sudden-onset, young-adult blindness (Wallace et al.
Since the discovery that Leber hereditary optic neuropathy (LHON) results from mutations in mitochondrial DNA (mtDNA), considerable attention has been focused on this alternative genome and on development of the scientific tools needed to study this remarkable genetic pathway (1, 2).

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