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Related to hereditary optic neuropathy: Leber hereditary optic neuropathy, LHON


Any disease affecting neurons.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.



a functional weakness of the nervous system accompanied by a decrease in the absolute threshold (also called the stimulus, or sensitivity, threshold); the condition is frequently congenital.

Neuropathy arises as a disturbance in the function of the autonomic nervous system owing to deleterious influences on the fetus as a whole (for example, infection in the pregnant mother, trauma, or poisoning) or on the individual embryonic cells (as occurs when the parents suffer from alcoholism). Family circumstances, upbringing, and illnesses suffered by the infant play a role in the pathogenesis of neuropathy. The symptoms usually emerge in childhood or adolescence. When neuropathy occurs in early childhood, disturbances of sleep and appetite are most characteristic; the infant has difficulty in falling asleep, awakes easily, suckles poorly, and frequently spits up. Later, vomiting occurs, and either diarrhea or constipation develop.

From the preschool years on, increased general excitability and the rapid onset of fatigue and exhaustion are observed, in addition to continued disturbances of sleep and appetite. Children who suffer from neuropathy blush easily in response to irritation. Motor hyperactivity, nervous tics, and stammering are frequent. In adolescence, autonomic-vascular instability becomes more acute, as evidenced by frequently occurring nervous palpitation, abrupt shifts in blood pressure, headaches, dizzy spells, and fainting spells. The prognosis is favorable, with the neuropathic symptoms usually disappearing with age.


Simson, T. Nevropatii, psikhopatii i reaktivnye sostoianiia mladencheskogo vozrasta. Moscow-Leningrad, 1929.
Sukhareva, G. E. Klinicheskie lektsii po psikhiatrii detskogo vozrasta, vol. 2. Moscow, 1959.


The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
Emoto, "Initial temporal field defect in Leber hereditary optic neuropathy," Japanese Journal of Ophthalmology, vol.
Davis et al., "Gene therapy for Leber hereditary optic neuropathy: initial results," Ophthalmology, vol.
Leber's hereditary optic neuropathy (LHON) is a heritable genetic disease causing blindness.
* The report provides a snapshot of the global therapeutic landscape of Leber's Hereditary Optic Neuropathy (LHON) (Leber optic atrophy)
Carelli, "Leber's hereditary optic neuropathy," Current Treatment Options in Neurology, vol.
De novo 14484 mitochondrial DNA mutation in monozygotic twins discordant for Leber's hereditary optic neuropathy. Neurology 1997; 49:1136-8.
(2003) The epidemiology of Leber hereditary optic neuropathy in the North East of England.
Santhera develops Catena/Raxone as treatment for patients with Leber's Hereditary Optic Neuropathy, Duchenne Muscular Dystrophy and Primary Progressive Multiple Sclerosis.
Washington, Aug 05 ( ANI ): By borrowing a tool from bacteria that infect plants, researchers have developed a new approach that can be used to treat a variety of mitochondrial diseases, including the degenerative eye disease Leber hereditary optic neuropathy (LHON).
Tylock has faced many challenges since being diagnosed in eighth grade with Leber's Hereditary Optic Neuropathy, a rare genetic disorder that causes loss of vision.
Over the years, most patients experience various degrees of visual recovery similar to that observed in Lebers' hereditary optic neuropathy, although they can continue to show abnormal visual evoked potentials and bilateral optic disk pallor [44, 74].
I know truck driver Scott, now a civil servant, lost his vision at 23 due to a condition called Leber's hereditary optic neuropathy. he can do it' He refused to let it slow him down and after taking up climbing with Travis, he founded a walking group called Travis Trek in 2003.

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