heterodimer


Also found in: Dictionary, Thesaurus, Medical.
Related to heterodimer: Homodimer, Heterodimerize

heterodimer

[‚hed·ə·rō′dī·mər]
(biochemistry)
A protein made of paired polypeptides that differ in their amino acid sequences.
References in periodicals archive ?
When the expression of LXR[alpha] gene is increased, more heterodimers could be formed by PPARI3 and RXR, inhibiting PPARI3 and RXR forming heterodimers and decreasing the expression of PPARI3 (Yoshikawa et al.
The p50/p65 heterodimer is the most important transcription factor of the canonical NF-[kappa]B pathway and is commonly referred to as NF-[kappa]B [38, 51].
Hla-DQ2 heterodimer in the diagnosis of celiac disease.
NF-[kappa]B proteins comprise members of the Rel/NF-[kappa]B family, forming homo- and heterodimers through a combination of the p65 (or RelA), p50, p52, c-Rel, or RelB subunits.
When AhR is activated by dioxins, it translocates into the nucleus and forms a heterodimer with its partner ARNT (aryl hydrocarbon receptor nuclear translocator).
Integrins are expressed on the cell surface as a noncovalently linked heterodimer consisting of [alpha] and [beta] subunit, which conveys specificity in cell-cell adhesion, cell-extracellular matrix (ECM) adhesion, immune cell recruitment, extravasation, and signaling [10].
In addition to stimulating phagocytosis, the heterodimer induces the expression of CYP27B1 and vitamin D receptor (VDR).
420]-reducing hydrogenase from methanogenic archaeon is an oligomer of trimers consisted of the core heterodimer and another subunit.
The ~14-kDa pro-peptide and the ~62-kDa PCSK9 then form a heterodimer, which transits through the Golgi apparatus, is secreted, and interacts with the LDLR.
1) Peroxisome proliferator-activated receptor (2) PPAR heterodimer with retinoid X receptor (3) Vitamin D receptor heterodimer with retinoid X receptor (4) Activator protein 2
This factor, an heterodimer including one of the three subunit alpha 1, 2, 3 and a beta subunit, activates the transcription of genes coding for proteins mediating the adaptive response to hypoxia, such as erythropoetin and some enzymes of the glycolytic pathway (3), (4).
These subunits are arranged as a disulfide-linked C8[alpha]-[gamma] heterodimer that is noncovalently associated with C8[beta].