heterodimer


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Related to heterodimer: Homodimer, Heterodimerize

heterodimer

[‚hed·ə·rō′dī·mər]
(biochemistry)
A protein made of paired polypeptides that differ in their amino acid sequences.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
The basic MMR machinery involves two families of proteins MutS and MutL convoluted to form heterodimers in contrast to bacteria, which function as homodimers.
Con: control group; FXR: farnesoid X receptor; SHP: small heterodimer partner; SREBP-1: sterol regulatory element binding protein-1; CYP7A1: cholesterol 7a-hydroxylase gene (CYP7A1); PEPCK: phosphoenolpyruvate carboxykinase; G6Pase: glucose-6-phosphatase; PPARa: peroxisome-proliferator-activated receptor a.
Anti-cleaved caspase 3 Asp 175 (#9661) was from Cell Signalling Technology (Hitchin, UK); anti-rabbit Alexa Fluor 488 from Life Technologies (Paisley, UK); and anti S100A8/S100A9 heterodimer from R&D systems (Abingdon, UK)
In the liver, the heterodimer FXR-RXR induces the expression of BSEP by binding to an IR-1 element at the promoter [34, 35].
After calcitriol binds to VDR, the conformation of VDR changes and then binds to the RXR to form a heterodimer, which enters the nucleus, binds to reactive elements of vitamin D, and promotes the transcription of vitamin D-related genes [11].
[[beta].sub.1]-AR and [[beta].sub.2]-AR can form heterodimers [11], where [[beta].sub.2]-AR downstream couples with stimulatory G protein ([G.sub.s]) and inhibitory G protein ([G.sub.i])[12].
A rather simplistic model explaining the activation of the cytoplasmic p65-p50 heterodimer speaks to IKK activation by phosphorylation of its serine (176) [73].
Collectively, our present study investigated the biodistribution and acute toxicity of [sup.125]I-radiolabeled [Fe.sub.3][O.sub.4]-Ag heterodimer NPs in mice.
CXCR2 is known to form heterodimers with other receptors, which can positively or negatively regulate each partner's response to its ligands and antagonists [17, 18].
Some studies have revealed that cholesterol-induced LPL gene expression in the liver is directly regulated by RXR/LXR heterodimers in a tissue-specific manner, which is mediated predominantly by LXR[alpha] in vivo (Zhang et al., 2001).
Epidemiologically, more than 95% of patients with CD share the HLA-DQ2 heterodimer, and the remainder present the HLA-DQ8 heterodimer (2).