heteroduplex


Also found in: Dictionary, Medical, Wikipedia.

heteroduplex

[‚hed·ə·rō′dü‚pleks]
(genetics)
A double-stranded deoxyribonucleic molecule comprising strands from different individuals.
(cell and molecular biology)
A double-stranded molecule of deoxyribonucleic acid in which the two strands show noncomplementary sections.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
Mentioned in ?
References in periodicals archive ?
The PAM dependent recruitment of the Cas9-sgRNA complex triggers the initiation of the DNA-sgRNA heteroduplex R-loop formation [60].
For example, MTHFR c.665C>T genotyping at 0.13[degrees]C/s had only a small heteroduplex peak.
Despite the negative report for the third isolation, no heteroduplex production and single base Displacement were seen on PAGE even after recheck and doubling the incubation time in the EDTA buffer (Fig.
Fifteen novel FBN1 mutations causing Marfan syndrome detected by heteroduplex analysis of genomic amplicons.
Heterozygous DNA samples formed heteroduplexes, resulting in a different shape of the melting curve compared with a homozygous sample.
The first lowest band was 191 bp DNA of normal alleles, the middle band represented 250 bp mutant DNA of exon-11, and the upper band was 300 bp heteroduplex DNA arising from the combination between normal and mutant DNA alleles, as shown in Figure 4.
This approach requires a treatment of the amplified DNA with CEL1 endonuclease or any of a number of single strand endonucleases, after heteroduplex formation between the DNA of lines to be investigated.
Identification of bloodmeals in haematophagous Diptera by cytochrome B heteroduplex analysis.
However, errors can occur due to allelic dropout, where females are miss-sexed as males (Arnold et al., 2003; Robertson and Gemmell, 2006) or due to the formation of heteroduplex DNA molecules, where males can be misidentified as females (Casey et al., 2009).
We analysed the BRCA2 gene using a novel high-throughput multiplex fluorescence heteroduplex detection system developed for the ABI3130xl genetic analyzer.