Progressive osseous heteroplasia
: a model for the imprinting effects of GNAS inactivating mutations in humans.
Some forms of OC have been reported as features of syndromes such as Albright hereditary osteodystrophy, fibrodysplasia ossificans progressiva and progressive osseous heteroplasia
In avian embryos, a lack of oxygen causes high foetal mortality, heteroplasia
, and cardiovascular dysfunction.
Differential Diagnosis: Progressive Osseus Heteroplasia
, Aggressive Juvenile Fibromatosis, soft tissue sarcomas, lymphomas and desmoids tumors are a few important ones to consider.
(6,12) The congenital type is seen in rare syndromes, including congenital plaque-like osteomatosis, Albright hereditary osteodystrophy, fibrodysplasia ossificans progressiva, and osseous heteroplasia
. (6) The more common acquired form usually occurs after musculoskeletal trauma (e.g., fracture, joint dislocation, or soft-tissue trauma) or orthopedic surgery (e.g., hip, knee, or shoulder arthroplasty).
Congenital (24) * three inherited diseases that are characterized by heterotopic bone formation (24) * these are: fibrousdysplasia ossificans progressive (FOP), progressive osseous heteroplasia
(POH), and Albright's hereditary osteodystrophy (AHO) * although rare, they should be included in children presenting with myositis ossificans of an idiopathic nature.