heterozygote advantage


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heterozygote advantage

[‚hed·ə·rō¦zī‚gōt ad′van·tij]
References in periodicals archive ?
Nouraie et al., "The heterozygote advantage of the chuvash polycythemia VHL R200W mutation may be protection against anemia," Haematologica, vol.
A well-established case of heterozygote advantage is that of the gene involved in sickle cell anaemia.
The concept of "heterozygote advantage"--when an animal benefits from having two different versions of a gene--isn't new, Johnston says.
With teacher guidance, students will become familiar with many genetics concepts: probability, dominant and recessive traits, sex-linked traits, penetrance, dosage compensation, Barr bodies, pleiotropy, founder effect, aneuploidies, environmental interactions, allele polymorphisms, heterozygote advantage, and the outcomes and ethics of genetic screening.
Yet, frequencies of these deleterious alleles are much higher in the Ashkenazi as compared to the general European population, raising the possibility of a selective heterozygote advantage for the carrier.
On the one hand, Annett (1993, 1995) proposes that rs+- persons should be best at all types of abilities, the so-called heterozygote advantage. On the other hand, Annett (1995, [ILLUSTRATION FOR FIGURE 3 OMITTED], p.
Heterozygote advantage for HLA class-II type in hepatitis B virus infection.
Theoretical considerations indicate that heterozygote advantage at marker loci can be caused by deleterious genes that are recessive or partially recessive and linked in repulsion, by true overdominant gene action, or by linkage to either case (Falconer, 1989).
Simulation studies, however, suggest that variability might not be lost as rapidly as indicated by Wright's model (Lesica and Allendorf 1992); selection for heterozygotes, whether heterozygote advantage results from overdominance or inbreeding or some other cause, could slow the loss of alleles.
Taking account of the further development of her theory (Annett & Manning, 1989, 1990a), there is a human balanced polymorphism for laterality and ability with heterozygote advantage. The benefits of left hemisphere specialization for speech are induced through a gene (rs +) which impairs right hemisphere functioning at some sensitive period of cerebral growth.
Researchers have suggested that the mutant cftr gene persists so widely because of a heterozygote advantage. That is, having one mutant copy of cftr and one normal copy is somehow beneficial.
[H.sub.l] is the heterozygote advantage (overdominance) at locus l (Log[1 + [H.sub.l]] values are additive as the fitness is assumed to be multiplicative across loci).