hexamethonium


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hexamethonium

[‚hek·sə·mə′thō·nē·əm ′klȯr‚īd]
(pharmacology)
One of a homologous series of polymethylene bis(trimethylammonium) ions, of the general formula [(CH3)3N(CH2)6N(CH3)3]2+, in which n is 6; possesses potent ganglion-blocking action, effecting reduction in blood pressure; used clinically as a salt, commonly bromide or iodide.
References in periodicals archive ?
Losartan (Figure 5(c)) and hexamethonium (Figure 5(e)) decreased blood pressure from 121.4 [+ or -] 7.56 x 84.2 [+ or -] 12.87 to 91.2 [+ or -] 11.23 x 49.4 [+ or -] 5.27 mmHg and 118.75 [+ or -] 7.41 x 74 [+ or -] 4.76 to 101.75 [+ or -] 7.18 x 50.25 [+ or -] 10.53 mmHg, respectively.
Nevertheless, it has been shown that atropine alone already improves the recovery of Fade induced by antinicotinic (hexamethonium, D-tubocurarine) agents in the anterior tibial muscle nerve preparation of cats (Prado, Corrado, & Prado, 1987).
Similarly, if the application of saponin was preceded by the administration of hexamethonium, the strength of the contraction of stomach fundus strips induced by [alpha]-hederin was not modified.
Roche was hexamethonium, which was not FDA approved for human use or for administration via inhalation.
According to Varmus: "Think about hexamethonium, the drug that killed a student at Johns Hopkins.
"Some of those volunteers would also be given hexamethonium, a so-called ganglionic blocker that would prevent signals from returning to the lungs--and, if the theory was right, stop the airways from reopening."
The capillary electrophoresis method recently under examination for the separation of poisonous anions in food consists of a 1.6-mM triethanolamine buffer (pH 7.7) containing 0.75 mM hexamethonium hydroxide and 2.25 mM pyromellitic acid (Harrold et al.
dioica, four groups of six SHR each were prepared for experimentation as outlined above but, autonomic ganglion (group 1), [alpha]-adrenoceptor (group 2), -[beta]adrenoceptor (group 3) and cholinergic receptor (group 4) blockades were produced by using a specific blocker (group 1: hexamethonium 20 mg/kg, group 2: phentolamine 2 mglkg, group 3: propranolol 0.4 mglkg and group 4: atropine 1 mg/kg).
The following drug stock solutions were made and used immediately or stored at -20 [degrees]C until required: 805 mmol [l.sup.-1] hexamethonium in water, 400 mmol [l.sup.-1] 2-aminoethoxydiphenyl borate (2-APB) in methanol, 10 mmol [l.sup.-1] diltiazem in water, 1 mmol [l.sup.-1] thapsigargin in dimethyl sulfoxide (DMSO), 10 mmol [l.sup.-1] N(G)-nitro- L-arginine methyl ester (L-NAME) in ASW, and 100 mmol [l.sup.-1] theophylline in water.
hexamethonium pretreatment, suggesting that it may result from vasodilatory action of EOAZ directly upon vascular smooth muscle rather than withdrawal of sympathetic tone (Lahlou et al.
It highlights the importance of health sciences librarians in light of librarians' roles in Hurricane Katrina and the Ellen Roche case, a volunteer in an asthma study who died after inhaling hexamethonium, a chemical that, if the researchers had gone back into the literature in the 1950s, would have been found to be dangerous.
These were inhibited by atropine, hexamethonium and ondansetron suggesting that cholinergic and 5-H[T.sub.3] receptors are involved in this mechanism.