hexobarbital


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hexobarbital

[¦hek·sə′bär·bə·tȯl]
(pharmacology)
C12H16N2O3 A sedative and hypnotic of short duration of action; used also, as the sodium derivative, to induce surgical anesthesia.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
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Like other barbiturates decreased duration of hexobarbital sleeping time is a well known indicator of impaired drug metabolism.
Effects of methyl mercury on hypnotic action of hexobarbital, liver hydroxylase and cytochrome P-450 in mice.
Using these genes in the analysis of blinded liver RNA samples exposed to phenytoin, diethylhexylpthalate, or hexobarbital allowed the authors to successfully predict whether these samples were derived from livers of rats exposed to enzyme inducers or peroxisome proliferators (Hamadeh et al.
The volatile fraction of the petroleum ether extract potentiated the sedative activity with pentobarbital, hexobarbital, and ethanol in mice (Dandiya and Cullumbine 1959).
Examples of some clinical applications for cyclodextrins in HPLC include methods reported for chlorpheniramine (158), citalopram, desmethylcitalopram, and didesmethylcitalopram (159), hexobarbital (158), the M1 and M2 metabolites of moguisteine (160), and propranolol (161).
In brief, male Wistar rats weighting 150-180 g were anesthetized with hexobarbital (40 mg/kg i.p.).
Stereoselective disposition of hexobarbital and its metabolites: relationship to the S-mephenytoin polymorphism in Caucasian and Chinese subjects.
The pharmacological properties of perillaldehyde were reported previously; they consist of antibacterial activity (Inouye et al., 2001; Friedman et al., 2002), inhibition of transformation of Candida albicans to a filamentous form (McGeady et al., 2002), and prolongation of sleeping time induced by the administration of hexobarbital (Sugaya et al., 1981).