Factors Influencing Misinterpretation of High-Grade Squamous Intraepithelial Lesion
Slides in the Interlaboratory Comparison Program in Cervicovaginal Cytology (PAP) Education and PAP Proficiency Test Programs (Nonlinear Mixed-Model Summary) PAP Education No.
"Low-grade squamous intraepithelial lesion, cannot exclude high-grade squamous intraepithelial lesion
" is a distinct cytologic category: histologic outcomes and HPV prevalence.
Follow-up findings in adolescents with high-grade squamous intraepithelial lesion
Papanicolaou test results.
High-grade squamous intraepithelial lesion
was the most-common, preceding, Pap test diagnosis (36.0%; 68 of 189), followed by LSIL (29.1%; 55 of 189), LSIL-H (16.4%; 31 of 189), and ASC-H (11.1%; 21 of 189) (Figure 4).
When asked which interpretive rates were felt to not be useful, most comments included relatively rare but significant interpretations such as atypical glandular cells, atypical squamous cells, cannot exclude high-grade squamous intraepithelial lesion
(ASC-H), and cancer.
Perhaps a more fruitful way to detect more false-negative Pap findings in retrospective rescreening is to also include cervical biopsy specimens diagnostic of a high-grade squamous intraepithelial lesion
or worse to trigger review.
MONDAY, July 22, 2019 (HealthDay News) -- The prevalence of anal high-grade squamous intraepithelial lesions
(HSILs), which precede anal cancer, is high among women living with HIV (WLHIV) in the United States, according to a study published online July 11 in Clinical Infectious Diseases.
Recruitment is already ongoing for patients who are HIV-positive with histologically confirmed anal high-grade squamous intraepithelial lesions
associated with HPV-16 and/or HPV-18.
Colposcopy has a mean 90% specificity for diagnosis of HPV-related high-grade squamous intraepithelial lesions
(HSIL) or cervical cancer, while high-resolution anoscopy as a diagnostic test has a specificity as low as 37% in HIV-positive persons.
This finding corroborates a previous study performed by us  that showed a progressive increase of VEGF immunoexpression in high-grade squamous intraepithelial lesions
when compared to low-grade squamous intraepithelial lesions and to benign squamous epithelium.
The topics include colposcopy, negative for intraepithelial lesion and malignancy, low-grade and high-grade squamous intraepithelial lesions
, atypical squamous cells of uncertain significance, adenocarcinoma, and cervical cancer screening and follow-up of limited and abnormal screen results.