Obstructive jaundice in children with histiocytosis X
. Gastroenterol 1981;80:134-9.
Pulmonary Langerhans cell granulomatosis (histiocytosis X
): a clinicopathologic study of 48 cases.
However, Lichtenstein coined the word "Histiocytosis X
" to refer to full disease.
Langerhans'-cell histiocytosis (histiocytosis X
)--a clonal proliferative disease.
(1) The hallmark of histiocytosis X
is the Langerhans cell, a histiocyte with characteristic racquet shaped Birbeck granules visible on electron microscopy.
The possibility of a histiocytosis X
should be considered in a young adult with a miliary pattern that is unresponsive to a long duration of antituberculosis drugs and corticosteroids, particularly in the absence of neurologic findings.
The condition has many synonyms, including histiocytosis X
, eosinophilic granuloma, and others.
INTRODUCTION: Langerhans cell histiocytosis is the name proposed by Risdall et al, (1) in 1983,for a group of disorders previously called histiocytosis X
; where langerhans cells play a central role in the pathogenesis.
Lichtenstein originated the term histiocytosis X
in 1953 to describe a group of poorly understood diseases that differed in presentation but had a common pathologic characteristic: histiocyte proliferation.
Lichenstein and Jaffe in 1953 included all these entities under the general category of Histiocytosis X
. The unification of these three separately described diseases was based on identical histopathologic features of the lesions, which were composed of eosinophils, histiocytes, and lymphocytes.
Primary histiocytosis X
of the parieto-occipital lobe.