histiocytosis

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histiocytosis

[‚his·tē·ō‚sī′tō·səs]
(medicine)
Abnormal proliferation of histiocytes, especially in hematopoietic tissues.
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1) The hallmark of histiocytosis X is the Langerhans cell, a histiocyte with characteristic racquet shaped Birbeck granules visible on electron microscopy.
DISCUSSION: Histiocytosis X is a clonal proliferation disease of langerhan's cells that express an immunophenotype positive for S100 and CD1a (7) Hand-schuller-christian disease is a well described entity which has appeared sporadically till 1935.
2-5) In 1987, the international Histiocyte Society changed the name of the disease from histiocytosis X to Langerhans' cell histiocytosis.
Lichenstein and Jaffe in 1953 included all these entities under the general category of Histiocytosis X.
In 1987, the Writing Group of the Histiocyte Society introduced the term Langerhans cell histiocytosis (LCH) to replace the old term histiocytosis X.
The term Histiocytosis X was suggested by Lichtenstein in 1953 which included a spectrum of disorders characterized by proliferation of histiocyte- like cells (1).