histiocytosis

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histiocytosis

[‚his·tē·ō‚sī′tō·səs]
(medicine)
Abnormal proliferation of histiocytes, especially in hematopoietic tissues.
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References in periodicals archive ?
Obstructive jaundice in children with histiocytosis X. Gastroenterol 1981;80:134-9.
Pulmonary Langerhans cell granulomatosis (histiocytosis X): a clinicopathologic study of 48 cases.
However, Lichtenstein coined the word "Histiocytosis X" to refer to full disease.
Langerhans'-cell histiocytosis (histiocytosis X)--a clonal proliferative disease.
(1) The hallmark of histiocytosis X is the Langerhans cell, a histiocyte with characteristic racquet shaped Birbeck granules visible on electron microscopy.
The possibility of a histiocytosis X should be considered in a young adult with a miliary pattern that is unresponsive to a long duration of antituberculosis drugs and corticosteroids, particularly in the absence of neurologic findings.
The condition has many synonyms, including histiocytosis X, eosinophilic granuloma, and others.
INTRODUCTION: Langerhans cell histiocytosis is the name proposed by Risdall et al, (1) in 1983,for a group of disorders previously called histiocytosis X; where langerhans cells play a central role in the pathogenesis.
Lichtenstein originated the term histiocytosis X in 1953 to describe a group of poorly understood diseases that differed in presentation but had a common pathologic characteristic: histiocyte proliferation.
Lichenstein and Jaffe in 1953 included all these entities under the general category of Histiocytosis X. The unification of these three separately described diseases was based on identical histopathologic features of the lesions, which were composed of eosinophils, histiocytes, and lymphocytes.