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see transplantation, medicaltransplantation, medical,
surgical procedure by which a tissue or organ is removed and replaced by a corresponding part, usually from another part of the body or from another individual.
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A term used to describe the genes that influence acceptance or rejection of grafts. When grafts of tissue are exchanged between genetically dissimilar individuals, profound immunological rejection generally takes place. In contrast, grafts between genetically similar individuals, such as identical twins, are normally tolerated; they are histocompatible. Most known examples of histocompatibility (or H) genes encode polymorphic (that is, tending to differ between individuals) cell-surface proteins.

The major histocompatibility complex (MHC) contains a set of histocompatibility genes, termed major because mismatching at these genes invokes rapid rejection. The main function of MHC genes involves distinguishing self from nonself in the immune system, as part of preventing the spread of infectious disease. The body employs special mechanisms to avoid rejection of the fetus, which is effectively an allograft, that is, a graft from a donor to a genetically dissimilar recipient of the same species; in this case, the mechanisms include a diminution of MHC gene expression.

The MHC contains a spectrum of genes, many of which influence processing and presentation of antigens to the immune system. In mice, the MHC is designated the H-2 complex; in humans, it is referred to as the HLA complex (for human leukocyte A system). Mice and other mammals seem to have a similar arrangement of genes in their MHCs. See Antigen, Cellular immunology, Mendelism, Transplantation biology


The capacity to accept or reject a tissue graft.
References in periodicals archive ?
Nehlin and Torben Barington, "Strategies for future histocompatible stem cell therapy," Biogerontology, 10, 4 (2009): 339; Marcel Leist et al.
Her parents wanted to have a second child who would not be afflicted with Fanconi's, and who also could be a histocompatible donor to Molly--a source of compatible cord blood.
I) AND adverts significantly and Kan Jang highly significantly the production of [gamma]2MG both in stimulated and non-stimulated lymphocytes in the cell culture, which is associated with an increased expression of class 1 histocompatible molecules,
Con la aparicion de los inmunosupresores como la ciclosporina en los anos setenta, para controlar el rechazo inmunologico, se abre un amplio espectro de opciones de vida para el 80 por ciento de los pacientes que normalmente no cuentan con un organo histocompatible y mueren.
How many children are there," he asks, "who need a transplant and have a histocompatible sibling about to be delivered?
Donated units of cord blood (CB) are processed and stored by the company for use in unrelated transplants (where the donor is a histocompatible match, but is anonymous and unrelated to the recipient) and for personal storage and use.
Kidney swaps may be employed if the relative and the person on the waiting list are not histocompatible.
We believe these cells are a real alternative to embryonic stem cells for obtaining a population of histocompatible, pluripotent stem cells for regenerative purposes.