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The developmental process by which the definite cells and tissues which make up the body of an organism arise from embryonic cells.



the development of tissues; the complex of natural processes that ensures the emergence, existence, and restoration of animal tissues and their specific properties in various organs.

The study of the histogenesis of various tissues and its principles is one of the most important aspects of histology. The term “histogenesis” is customarily used to designate the ontogenetic development of tissues. However, the patterns of histogenesis cannot be regarded separately from the evolutionary development of tissues. The basis of histogenesis is cell differentiation (the development of growing morphological and functional differences between newly specializing cells), which begins during the earliest stages of embryonic development. This is a complex molecular-genetic process that regularly involves the activity of the genes that determine the specifics of protein syntheses in the cell. The multiplication of cells, their relative migrations, and other processes lead to the formation of embryonic rudiments, which consist of groups of cells distributed according to a regular pattern in the body of the embryo. The entire diversity of tissues of various organs of the body arises as a result of the tissue differentiation of these embryonic rudiments.

During the postembryonic period the processes of histogenesis are divided into three basic types: the processes within tissues whose cells do not multiply (for example, in nervous tissue), those in tissues whose cell division is associated primarily with the growth of the organ (for example, in the parenchyma of the digestive glands and kidneys), and those in tissues characterized by constant cell renewal (for example, in hemopoietic tissue and many integumental epithelia). Cells that effect definite histogenesis are subdivided into a series of successive groups, including a stock of parent cells, capable of differentiation as well as of making up a loss of its own kind; a stock of precursor cells that undergo differentiation and are capable of division; and a stock of mature cells that have completed differentiation. The regeneration of damaged or partially depleted tissues after injury is accomplished through so-called reparative histogenesis. Under pathological conditions the processes of histogenesis may undergo profound qualitative changes and lead to the development of tumorous tissues.


Khlopin, N. G. Obshchebiologicheskie i eksperimental’nye osnovy gistologii. Moscow, 1946. (Bibliography.)
Zavarzin, A. A. “Ocherki evoliutsionnoi gistologii krovi i soedinitel’noi tkani.” Izbr. trudy, vol. 4. Moscow-Leningrad, 1953.
Krushchov, N. G. Funktsional’naia tsitokhimiia rykhloi soedi nitel’noi tkani. Moscow, 1969. (Bibliography.)


References in periodicals archive ?
Histiocytosis X: Histogenetic arguments for a Langerhans cell origin.
Spindle cell lipoma-like tumor, solitary fibrous tumor and myofibroblastoma of the breast: a clinic-pathologic analysis of 13 cases in favor of a unifying histogenetic concept.
Extraventricular neurocytomas: a morphological and histogenetic consideration--a study of six cases.
8-12) In the current histogenetic model of TGCTs, embryonal carcinoma may arise from seminoma through transformation.
On the whole, these findings are in agreement with most of the relevant published reports in which consistent keratin immunostaining with the additional support of calretinin was shown to be a useful and sensitive method for distinguishing sarcomatoid MM from sarcomas of different histogenetic types.
In particular, it may not be possible to distinguish by immunohistochemistry alone between the 2 histogenetic theories in the absence of characterizable well-defined entrapped epithelial rests as a reference.
In their studies, electron microscopy was used to demonstrate a transition from mitochondrial-rich cylindrical cells to squamous cells, although the exact histogenetic sequence could not be reconstructed.
Traditionally, the melanomas are classified into one of the several well-defined histogenetic subtypes: superficial spreading, lentigo maligna, acral lentiginous, and nodular (6,7) (Figure 1, A through C).
The clinical diagnosis, classification and histogenetic concepts of the early stages of cutaneous malignant melanomas.
Renal angiomyolipoma: an ultrastructural investigation of three cases with histogenetic considerations.
ETV6-NTRK3 gene fusions and trisomy 11 establish a histogenetic link between mesoblastic nephroma and congenital fibrosarcoma.
The pattern of expression of kidney-specific cadherin in other, more recently described, types of renal tumor (66% in Xp11 translocation RCCs and 77% in MTSCCs) carry both diagnostic and histogenetic significance.