homocysteine


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homocysteine

[¦hä·mə′sis·tēn]
(biochemistry)
C4H9O2NS An amino acid formed in animals by demethylation of methionine.
References in periodicals archive ?
Conclusion: Systolic blood pressure and duration of diabetes showed a significant positive correlation with homocysteine. The correlation of homocysteine with HbA1c was not certain from researcher's point of view and further studies of larger sample size and longer duration must be conducted to ascertain the association between the two variables.
The link between Alzheimer's and homocysteine is not speculative, either; on the contrary, what has been dubbed "the homocysteine hypothesis" is based upon the observation that Alzheimer's patients have significantly elevated serum concentrations of homocysteine.
The comparison of homocysteine level between healthy controls and PXS patient s showed a highly significant (p-value<0.01) difference between both groups.
* High total plasma homocysteine is strongly associated with age-related hearing loss.
Data regarding association of homocysteine and subclinical hypothyroidism is very limited in North-East India.
Subsequently, plasma serum homocysteine, glucose, total lipid profile concentration, ESR, forearm blood flow, and vascular resistance were determined.
Furthermore, in the research conducted on PD patients, homocysteine level of cerebrospinal fluid has been reported higher than normal [11].
Homocysteine is a sulfur-containing amino acid that is derived from the metabolism of methionine (Met), which is rapidly oxidized in plasma to the disulfides homocysteine and cysteine-homocysteine.[sup][7] Met can be converted to S-adenosylmethionine (SAM), which is catalyzed by methionine adenosyltransferase.
High levels of homocysteine have been shown to increase the risk of&nbsp;(http://circ.ahajournals.org/content/111/19/e289) hardening of the arteries &nbsp;(atherosclerosis), which could eventually result in a heart attack and/or stroke, and&nbsp;(http://www.fvleiden.org/ask/77.html) blood clots in the veins , referred to as venous thrombosis.
Methionine and homocysteine are two very important amino acids.
The "homocysteine theory" of atherosclerosis came up from the observation that diseases such as homozygous homocystinuria, which are characterized by severe hyperhomocysteinemia are associated with premature vascular disease.