homologous recombination


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homologous recombination

[hə¦mäl·ə·gə ‚re·käm·bə′nā·shən]
(genetics)
Deoxyribonucleic acid exchange between identical chromosome regions on homologous chromosomes that occurs naturally during meiosis.
References in periodicals archive ?
"Homologous Recombination technology in plants heralds fundamental major scientific advances for applications in plant biotechnology.
A possible explanation is that, despite the evidence of high frequency of DNA DSBs evidenced by the number of [gamma]H2AX foci, the tumour cells have a poor ability to perform subsequent DNA repair by homologous recombination resulting in paradoxically low SCE frequency.
Liu, "Regulation of homologous recombination in eukaryotes," Annual Review of Genetics, vol.
[9.] Cui C, Song Y, Liu J, et al Gene targeting by TALEN-induced homologous recombination in goats directs production of p-lactoglobulinfree, high-human lactoferrin milk.
The homologous recombination pathway is complex and involves a number of genes.
In campylobacter, antigenic variation of Surface layer proteins (SLPs) is the result of homologous recombination that leads to its antigenic variation.
Lehman, "Herpes simplex virus type 1 DNA replication is specifically required for high-frequency homologous recombination between repeated sequences," Journal of Virology, vol.
In our current study, we estimated the effects of transformation conditions (plating methods, DNA topology, Ca[Cl.sub.2] treatment, recovery buffer, growth phase of cells, DNA volume, and flanking region length) on homologous recombination efficiency and optimized the transformation protocol for PCR tailing.
In dam-suppressor mutants, Chr1 and Chr2, fusions had occurred either by homologous recombination between IS elements or site-specific recombination between difsites.
Two major pathways operate in eukaryotic cells in the repair of endogenously or exogenously induced DSBs: nonhomologous end-joining (NHEJ) and homologous recombination (HR).
This cassette was integrated into the target site by homologous recombination using the clustered regularly interspaced short palindromic repeats/CRISPR-associated proteins 9 (CRISPR/Cas9) nickase system [6-8].