exhibited an ability to compete with other microorganisms for the synthesis of metalloenzymes such as acyl homoserine
lactonases, so that it can be used in the biotransformation of biowastes (Kumar et al.
Interaction of N-3-oxododecanoyl homoserine
lactone with LasR protein of Pseudomonas aeruginosa: insights from molecular docking and dynamics simulations.
pylori possess the ability to express a homologous gene for luxS, involved in the production of N-acyl homoserine
lactones (AHLs) associated with the quorum-sensing process, and AI-2 is a primary example of these molecules (30,31).
Bitter and sweet taste receptors (T2R and T1R, resp.) are G-protein-coupled receptors expressed in respiratory epithelia (reviewed in ) that are activated by quorum-sensing molecules such as homoserine
lactones from Pseudomonas aeruginosa or sugars.
Prevention of biofilm formation by SA causes an indiscriminate change in cell density while simultaneously targeting and blocking the production of QS-signaling peptides, such as acyl homoserine
lactones (AHLs), by inhibiting QS-regulated genes expression in Pseudomonas aeruginosa [19, 20].
Numerous abiotic factors including salinity, temperature, oxygen level, nutrient type and availability, level of antibiotic and its spectrum of activity, as well as the presence of signaling molecules such as homoserine
lactones are known to cause waxing or waning of particular bacterial species numbers.
Classes of compounds detected by the NMR method included amino acids (alanine, asparagine, arginine, cysteine, glycine, glutamate, glutamine, homoserine
, isoleucine, leucine, lysine, methionine, phenylalanine, sarcosine, serine, threonine, tyrosine, taurine, valine); alcohols (methanol and glycerol); ketones and fatty acid by-products (acetoacetate, acetate, 3-hydroxybutyrate, acetone, pyruvate, isobutyrate); sugar (glucose); other small molecule intermediates (o-phosphocholine, choline, n,n-dimethylglycine, citrate, creatine, lactate, methylhistidine, succinate, myo-inositol, dimethylamine, methylsuccinate, and 2-hydroxyisobutyrate).
FPEs contain abundant nutrients, such as alpha-tocopherol , flavonoid , glutamic acid, cystine, cytosine, nicotinic acid, pipecolic acid, homoserine
, quinic acid, and glucuronic acid, which possess antioxidant and antitumor functions.
Additionally, more complexes of naturally derived tetramic acids have been reported, the most important being those of decylidene tetramic acid (C12-TA), a degradation product derived from 3-oxododecanoyl homoserine
lactone (3-oxo-[C.sub.12]-HSL) that binds essential metals such as Fe(III) and Ga(III) ions .
SLE patients had reduced levels of homoserine
lactone and N-acetylmuramic acid and increased level of ribose-1,5-bisphosphate, which, in contrast to healthy subjects, were not influenced by body mass index (BMI) .
Alanine (Ala), arginine (Arg), aspartic acid (Asp), asparagine (Asn), glutamic acid (Glu), glutamine (Gin), serine (Ser) and theanine, major amino acids in the tea leaves, were measured by HPLC as described above using homoserine
as an internal standard (Goto et al., 1993).
Babu, "Direct lactonization of a-amino [gamma], [delta]-unsaturated carboxylic acid esters via olefin activation: stereo- and regioselective production of homoserine
lactone scaffolds having contiguous stereocenters," Tetrahedron, vol.