homovanillic acid


Also found in: Medical, Wikipedia.

homovanillic acid

[¦hä·mə·və¦nil·ik ′as·əd]
(biochemistry)
HOC6H3(OCH3)CH2CO2H A major metabolite of 3-O-methyl dopa; used in enzyme determination. Abbreviated HVA.
Mentioned in ?
References in periodicals archive ?
In the OAT we measure both homovanillic acid (dopamine metabolite) and vanillylmandelic acid (norepinephrine metabolite).
For this reason, the urine catecholamine metabolites, vanillylmandelic acid (VMA) and homovanillic acid (HVA), are often used to aid in the diagnosis of neuroblastoma.
Elevation of catecholamine metabolite secretions, including urinary vanillylmandelic acid (VMA), homovanillic acid (HVA), and dopamine, occurs in as many as 90% of pediatric patients [4] but is generally not seen in adolescents and adults.
Ganglioneuroblastomas have a propensity for secreting catecholamines, and approximately 90-95% actively secretes vinylmandelic acid (VMA) and homovanillic acid (HVA).
The levels of Dopamine (DA) and Homovanillic acid (HVA) in striatum were determined by Ultra-performance liquid chromatography combined with time-of-flight mass spectrometry (UPLC-ToF-MS).
Although other metabolites, such as homovanillic acid and hydroxymethylmandelic acid have been used for diagnosis in the past, it is now agreed that MN, NMN, and 3MT have much better sensitivity and specificity.
9] Homovanillic acid (HVA), vanillylmandelic acid (VMA) and acidic metabolites of catecholamines are excreted in higher than normal amounts by patients with neuroblastoma, and can therefore be used as tumour markers for diagnosis.
Serum and urine catecholamine levels showed mild elevation of serum homovanillic acid (HVA) and urine vanillylmandelic acid (VMA).
Homovanillic acid and 5-hydroxyindole-acetic acid in the CSF of patients after a severe head injury: I.
Metoclopramide induces catalepsy and increases striatal homovanillic acid content in mice.
2006) elegantly demonstrated that dopaminergic markers in the serum, namely prolactin and homovanillic acid, are affected in children exposed to cadmium, lead, mercury, and arsenic.