homozygote


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homozygote

(hō'mōzī`gōt): see geneticsgenetics,
scientific study of the mechanism of heredity. While Gregor Mendel first presented his findings on the statistical laws governing the transmission of certain traits from generation to generation in 1856, it was not until the discovery and detailed study of the
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The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.

Homozygote

 

a cell or an organism in whose genetic makeup the homologous chromosomes carry the identical form of a given gene. A homozygote originates during the fusion of gametes that are identical for a given gene. The genetic formula of a diploid organism homozygous for allele A or a can be written in the form AA or aa; for a triploid organism, AAA or aaa; and so forth.

The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.

homozygote

[¦hō·mə′zī‚gōt]
(genetics)
An individual who has identical alleles at one or more loci and therefore produces identical gametes with respect to these loci.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
Hence, in wild-type alleles (135 GG), the amplified fragment was digested using Mval (Thermo Scientific, Waltham, MA, USA) producing 86 and 71 bp products, whereas in 135 CC homozygotes, it was not digested resulting in a single 157 bp product.
In the present study, individuals harboring mutant homozygote AA showed a more effective response to fentanyl than those with GG or GA.
In agreement with our results, Qi et al, (15) identified TT homozygote genotype of ABCA1 C-565T polymorphism as a significant risk factor for CAD development.
A significant increased risk in the homozygote model (GG versus AA: OR= 1.72, 95% CI 1.19-1.49, [P.sub.H] = 0.24) was observed, while no significant association was found in other models (G versus A: OR= 1.08, 95% CI 0.92-1.28, [P.sub.H] = 0.38; GA versus AA: OR = 0.62, 95% CI 0.29-1.35, [P.sub.H] < 0.001; GG + GA versus AA: OR = 0.81, 95% CI 0.66-1.00, [P.sub.H] = 0.17; and GG versus GA + AA: OR= 1.74, 95% CI 0.68-4.49, [P.sub.H] = 0.016).
Frequency Genotype (percent) Heterozygote 17(40) E148Q 7(16) M694V 5(12) M680I(G>C) 2(5) P369S 1(2) V726A 1(2) M694I 1(2) Compound heterozygote 16(37) M694V/R761H 4(9) M694I/R761H 2(5) M680I/E148Q 2(5) M680I/M694V 3(7) P369S/E148Q 1(2) E148Q/M694I 1(2) M694V/V726A 1(2) M680I/R761H 1(2) V726A/R761H 1(2) Homozygote 9(21) M694V/M694V 4(9) M680I/M680I 3(7) V726A/V726A 2(5) Complex alleles mutations P369S/ E148Q/ E148Q 1(2) Table 2: Frequency of mutations in Familial Mediterranean Fever patients and parents.
In terms of INR levels of the patient group, no statistical difference was found between VKORC 1 and CYP2C9 haplotypes (p=0.305 and p=0.088, respectively), whereas a significant difference was found on weekly warfarin dosages of VKORC 1 homozygote normal GG and CYP2C9 *1/*1 homozygote normal (wild) carriers (p=0.02 and p=0.034, respectively) (Table 4).
The aim of the current study is to isolate homozygous [alpha]GT KO cells from postnatal heterozygous [alpha]GT KO skin fibroblasts and ultimately to evaluate the developmental competence of isolated homozygote cells after SCNT.
Our selected group c.35delG genotype N (%) (familial cases) Homozygote WT* 109 (82.6%) Only the deaf Heterozygote 35delG 2 (1.5%) Homozygote 35delG 21 (15.9%) Total 132 Homozygote WT* 291 (86.3%) All subjects Heterozygote 35delG 25 (74%) Homozygote 35delG 21 (6.2%) Total 337 *WT: wild type.
Each dot point represents a different homozygote. Homozygous haplotypes for MPRIP-TCAP region only.
L: Ladder 100bp; C+: positive control; C-: negative control; CC: cleavage control; S1: homozygote genotype AA; S2: heterozygote genotype AG; S3: homozygote genotype GG; S4: homozygote genotype AA; S5: heterozygote genotype AC; S6: homozygote genotype CC.