Homozygosis

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Related to homozygotic: monozygotic, Monozygotic twins

Homozygosis

 

the state of the genetic apparatus of an organism in which homologous chromosomes have the identical form of a given gene. The transition of a gene into the homozygous state leads to the manifestation in the organism’s structure and function (phenotype) of recessive alleles, whose effect in heterozygosis is suppressed by the dominant alleles. A test for homozygosis is the absence of splitting in certain forms of crossbreeding. A homozygous organism produces only one form of gamete for a given gene.

References in periodicals archive ?
Both homozygotic polymorphisms arg/arg and pro/pro along with TP53 gene mutation may cause worse prognosis.
First, a given [Mathematical Expression Omitted] can be due to a high genomic mutation rate ([Lambda]) producing mutations with low expected quadratic effect ([Mathematical Expression Omitted], a being the homozygotic effect on the trait of a new mutation) or, conversely, to low [Lambda] with high E([a.
It is lethal in homozygotic form and severely disadvantageous in heterozygotic form (in the absence of the new a-gene, and the odds are highly in favour of the a-gene being absent).
There is a requirement for Animals Models from Library Stocks and Strains, and also for the production of heterozygotic and homozygotic Transgenic animal models from genetic information supplied.
And non-enteric phenotypes in the population could only expressed by homozygotic mutations.
Homozygotic WT mice (C57BL/6) were purchased from Charles River Laboratories (Arbresle, France), and the inactivation of the AhR gene was performed to produce AhR-KO mice as described else-where (Fernandez-Salguero et al.
It is also demonstrated that these SE alleles show a dose effect with homozygotic individuals carrying increased risk over heterozygotes and some compound heterozygotes reveal a greater risk indeed, for example, the heterozygous combination of DRB1*0401/*0404 is identified to be strongly associated with early onset and a more severe form of disease than homozygosity for either allele (13, 14).
The identification of several rare homozygotic mutations adds useful information to the genotype-phenotype correlation for this disease.
involved genotypically well-characterized and presumably highly homozygotic parents (Aung & Walton, 1990).
In its simplest form, this model postulates that individuals homozygotic for the D allele (DD genotype) are all right-handed, those homozygotic for the C allele (CC genotype) are equally likely to be left- or right-handed, while heterozygotes (DC genotype) have a .