Homozygosis

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Related to homozygotic: monozygotic, Monozygotic twins
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.

Homozygosis

 

the state of the genetic apparatus of an organism in which homologous chromosomes have the identical form of a given gene. The transition of a gene into the homozygous state leads to the manifestation in the organism’s structure and function (phenotype) of recessive alleles, whose effect in heterozygosis is suppressed by the dominant alleles. A test for homozygosis is the absence of splitting in certain forms of crossbreeding. A homozygous organism produces only one form of gamete for a given gene.

The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
Both homozygotic polymorphisms arg/arg and pro/pro along with TP53 gene mutation may cause worse prognosis.
The hypothetical gene could induce left-handedness 25% of the time in heterozygotic persons, but all homozygotic recessives would be sinistrals and all homozygotic dominants would be dextrals.
This is because the most important effect of inbreeding is the high probability of producing homozygotic offspring (who have inherited the same allele for a given gene from both parents), because the offspring of related parents have a relatively higher chance of inheriting the same form of a gene from each parent.
First, a given [Mathematical Expression Omitted] can be due to a high genomic mutation rate ([Lambda]) producing mutations with low expected quadratic effect ([Mathematical Expression Omitted], a being the homozygotic effect on the trait of a new mutation) or, conversely, to low [Lambda] with high E([a.sup.2]) values.
It is lethal in homozygotic form and severely disadvantageous in heterozygotic form (in the absence of the new a-gene, and the odds are highly in favour of the a-gene being absent).
And non-enteric phenotypes in the population could only expressed by homozygotic mutations.
Homozygotic WT mice (C57BL/6) were purchased from Charles River Laboratories (Arbresle, France), and the inactivation of the AhR gene was performed to produce AhR-KO mice as described else-where (Fernandez-Salguero et al.
It is also demonstrated that these SE alleles show a dose effect with homozygotic individuals carrying increased risk over heterozygotes and some compound heterozygotes reveal a greater risk indeed, for example, the heterozygous combination of DRB1*0401/*0404 is identified to be strongly associated with early onset and a more severe form of disease than homozygosity for either allele (13, 14).
The identification of several rare homozygotic mutations adds useful information to the genotype-phenotype correlation for this disease.
involved genotypically well-characterized and presumably highly homozygotic parents (Aung & Walton, 1990).