human myeloma protein

[‚hyü·mən ‚mī·ə‚lō·mə ′prō‚tēn]

(immunology)

Any of a group of the first structurally discrete immunoglobulins known, resulting from the malignant expansion of a normal clone of antibody-producing cells.

References in periodicals archive ?

Fc and Fab and F (ab') 2 fragments were produced from several purified human myeloma proteins of each of the IgG subclasses, by pepsin and papain digestion (16).

Since three of our MAbs (1F5A8, 6F11E1 and 8F9G7) displayed similar binding activity to SPA with regard to interaction with purified human myeloma proteins of IgG1, 2 and 4 and the IgG3 myeloma protein Goe, as well as human polyclonal IgG1, 2 and 4, but not IgG3 subclasses (Figure 1), the specificity of these MAbs resembled that of SPA.

Production and characterization of mouse monoclonal antibodies recognizing multiple subclasses of human IgG

Fc, Fab and F (ab') 2 fragments were prepared from several purified human myeloma proteins of each of the IgG subclasses, by pepsin and papain digestion (17).

Generation and characterization of mouse hybridomas secreting monoclonal antibodies specific for human IgG3