It provides quantitation of erythrocytes and leukocytes, semi-quantitative assessment of bacteria, epithelial cells, and
hyaline casts, and qualitative evaluation of pathologic casts, crystals, yeast, sperm, and mucus.
RBC, WBC, squamous epithelial cells,
hyaline casts, and bacteria are enumerated.
Urinalysis showed large blood and
hyaline casts. Toxicology and heavy metal screenings were unremarkable.
The presence of pathologic casts or other particles was not confirmed in one-half of the cases because high numbers of
hyaline casts, ECs, and cell debris also can cause such flags.
Patients with chronic nephrotoxicity have focal acute tubular necrosis characterized by cystic dilated tubules lined by a flattened epithelium showing atypical nuclei and atypical mitotic figures with
hyaline casts. Long-term cisplatin treatment and injury may cause cyst formation and interstitial fibrosis.
The analyzer classifies images into categories including RBC, WBC, WBC clumps,
hyaline casts, unclassified casts, EC, nonsquamous EC, bacteria, yeast, crystals, mucus, sperm, and amorphous substances.
Quantitative counts were obtained for bacteria (BACT channel, counting particles with diameter [greater than or equal to] 2 [micro]m), RBCs, white blood cells (WBCs), casts (CAST channel; gated to detect mainly inclusion-bearing granular or cellular casts because
hyaline casts are difficult to discern from slime threads with such an analyzer), large epithelial cells (ECs), and small round cells (SRCs; including both epithelial and inflammatory cells).
Urinalysis showed proteinuria (>500mg/dl), moderate hemoglobinuria,
hyaline casts (41/LPF), WBC (28/HPF), and RBC (81/HPf).