Histological examination showed (b, c, and d) hypocellular myxoid and hypercellular areas containing stellate and spindle-shaped malignant cells with scattered bizarre multinucleated giant cells, (e) the presence of cytoplasmic eosinophilic hyaline globules
(arrow), and (f) cords of hepatocytes and bile ducts entrapped within the tumor (hematoxylin and eosin stain; original magnification: (b) x100; (c, d, and f) x200; (e) x400).
Eosinophilic and periodic acid-Schiff (PAS)-positive hyaline globules
are a common finding in advanced KS lesions.
Of additional help, solid-pattern yolk sac tumor frequently contains intracytoplasmic hyaline globules
and extracellular basement membrane deposits (Figure 1, F), (32) features that are rarely found in seminomas.
(12) Other reported findings include cytoplasmic eosinophilic hyaline globules
, nuclear grooving, and myxoid stroma.
Periodic acid-Schiff-positive, diastase-resistant hyaline globules
were detected within the cytoplasm of smooth muscle cells in 4 of 16 hepatic AMLs and 3 of 16 renal AMLs.
The oncocytic cells had granular eosinophilic cytoplasm, and some contained pale bodies and cytoplasmic hyaline globules
(Figure 2, A).
Characteristically, intracellular and rarely extracellular periodic acid-Schiff-positive hyaline globules
may be present.