hyaluronic acid

Also found in: Dictionary, Thesaurus, Medical, Acronyms, Wikipedia.

hyaluronic acid:

see mucopolysaccharidemucopolysaccharide
, class of polysaccharide molecules, also known as glycosaminoglycans, composed of amino-sugars chemically linked into repeating units that give a linear unbranched polymeric compound.
..... Click the link for more information.
The Columbia Electronic Encyclopedia™ Copyright © 2013, Columbia University Press. Licensed from Columbia University Press. All rights reserved. www.cc.columbia.edu/cu/cup/

Hyaluronic acid

A polysaccharide which is an integral part of the gel-like substance of animal connective tissue; it supposedly serves as a lubricant and shock absorbent in the joints. Hyaluronic acid has also been isolated from umbilical cord, synovial fluid, skin, certain fowl tumors, and other sources. Treatment of this polysaccharide with the enzyme hyaluronidase, followed by acid hydrolysis, yields a disaccharide consisting of N-acetyl- d -glucosamine and d -glucuronic acid. This disaccharide appears to be the basic repeating structural unit that constitutes the hyaluronic acid molecule. See Hyaluronidase, Polysaccharide

McGraw-Hill Concise Encyclopedia of Bioscience. © 2002 by The McGraw-Hill Companies, Inc.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.

Hyaluronic Acid


an acidic mucopolysaccharide that consists of repeating units of α-glucuronide-N-acetylglucosamine:

It is widespread in animal and human tissues. Molecular weight, 200,000-500,000 and higher. Present in skin, synovia, and the coverings of egg cells. Hyaluronic acid is an important component of the main material of connective tissue. Its solutions are very viscous; therefore, it can reduce the penetrability of tissues, preventing pathogens from penetrating into them.

Hyaluronic acid is rapidly metabolized in the body, where its half-life is two days. The enzymatic hydrolysis of hyaluronic acid to acetylglucosamine and glucuronic acid is effected by hyaluronidase, which is present in the walls of pathogens, semen, the salivary secretions of leeches, rapidly growing tumors, and snake, spider, and bee venom. The hyaluronidase of microbes and venom, which destroys the hyaluronic acid of intercellular material, promotes the spread of infection deep inside body tissues. Sperm hyaluronidase, in destroying the follicular layer of the egg cell, creates favorable conditions for its fertilization.

Hyaluronidase is used as a medicinal preparation to accelerate liquid absorption when the body is dehydrated, as a factor to facilitate the rapid penetration of anesthetics, and to promote the growth of connective tissue after various traumas.


The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.

hyaluronic acid

[¦hī·ə·lu̇¦rän·ik ′as·əd]
A polysaccharide found as an integral part of the gellike substance of animal connective tissue.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
Hyaluronic acid is one of the most potent weapons for fighting skin aging and preserving youthful skin.
Collagen and hyaluronic acid play a key role as components of many tissues such as skin, cartilage and bone.
I have several product suggestions containing hyaluronic acid. From Kiehl's, there's the Super Multi-Corrective Cream.
Thirty patients with osteoarthritis of the knee were evaluated in this Descriptive Comparative study comparing the efficacy of intra-articular hyaluronic acid with intra-articular triamcinolone hexacetonide.
After we do sequential action steps, we got a partial enzyme purity,take the bacteria growth of overnight broth culture with hyaluronic acid to produce the Hyaluronidase the enzyme degradation of hyaluronic acid (HA, hyaluronan), used centrifuge, Take the supernatant containing extracellular hyaluronidase.
Visit the Hyaluronic Acid Injections Market 2013-2020 report at https://www.ihealthcareanalyst.com/report/hyaluronic-acid-injections-market/
Joint Bursts combine collagen type 2, turmeric and hyaluronic acid into soft chews.
In this study, researchers tested the effects of hyaluronic acid that they administered orally and intravenously to male rats.
Found naturally in the body hyaluronic acid holds 1000 times its own weight in water.
Found naturally in the body, hyaluronic acid holds 1,000 times its own weight in water.
Hyaluronic acid is a linear, high molecular weight, non-sulfated glycosaminoglycan polysaccharide composed of repeating disaccharide units of alternating D-glucuronic acid and N-acetylglucosamine by [beta]-1,3 and [beta]-1,4 bonds (KOGAN et al., 2007).
Hyaluronic Acid: Preparation, Properties, Application in Biology and Medicine