hyaluronic acid

Also found in: Dictionary, Thesaurus, Medical, Legal, Acronyms, Wikipedia.

hyaluronic acid:

see mucopolysaccharidemucopolysaccharide
, class of polysaccharide molecules, also known as glycosaminoglycans, composed of amino-sugars chemically linked into repeating units that give a linear unbranched polymeric compound.
..... Click the link for more information.

Hyaluronic acid

A polysaccharide which is an integral part of the gel-like substance of animal connective tissue; it supposedly serves as a lubricant and shock absorbent in the joints. Hyaluronic acid has also been isolated from umbilical cord, synovial fluid, skin, certain fowl tumors, and other sources. Treatment of this polysaccharide with the enzyme hyaluronidase, followed by acid hydrolysis, yields a disaccharide consisting of N-acetyl- d -glucosamine and d -glucuronic acid. This disaccharide appears to be the basic repeating structural unit that constitutes the hyaluronic acid molecule. See Hyaluronidase, Polysaccharide

Hyaluronic Acid


an acidic mucopolysaccharide that consists of repeating units of α-glucuronide-N-acetylglucosamine:

It is widespread in animal and human tissues. Molecular weight, 200,000-500,000 and higher. Present in skin, synovia, and the coverings of egg cells. Hyaluronic acid is an important component of the main material of connective tissue. Its solutions are very viscous; therefore, it can reduce the penetrability of tissues, preventing pathogens from penetrating into them.

Hyaluronic acid is rapidly metabolized in the body, where its half-life is two days. The enzymatic hydrolysis of hyaluronic acid to acetylglucosamine and glucuronic acid is effected by hyaluronidase, which is present in the walls of pathogens, semen, the salivary secretions of leeches, rapidly growing tumors, and snake, spider, and bee venom. The hyaluronidase of microbes and venom, which destroys the hyaluronic acid of intercellular material, promotes the spread of infection deep inside body tissues. Sperm hyaluronidase, in destroying the follicular layer of the egg cell, creates favorable conditions for its fertilization.

Hyaluronidase is used as a medicinal preparation to accelerate liquid absorption when the body is dehydrated, as a factor to facilitate the rapid penetration of anesthetics, and to promote the growth of connective tissue after various traumas.


hyaluronic acid

[¦hī·ə·lu̇¦rän·ik ′as·əd]
A polysaccharide found as an integral part of the gellike substance of animal connective tissue.
References in periodicals archive ?
Table (4) compares the efficacy of hyaluronic acid with triamcinolone hexacetonide with reference to KGMC score on the 30th day of treatment.
In order to determine the mechanism of action of YE, the expression of mRNA coding for HAS2, the essential enzyme for the natural production of hyaluronic acid, (11) was assayed by quantitative PCR in these same normal human fibroblasts.
Hyaluronic acid production by Streptococcus zooepidemicus ATCC 39920 were performed through the control of the fermentation variables by factorial design and analysis of the response surface method.
With science driven marketing, Kewpie is now enjoying significant market share of hyaluronic acid containing beauty foods in Japan.
Hyaluronic acid is taking the beauty industry by storm as it is hailed as the natural alternative to Botox.
In the interim analysis, 71 percent of patients who received a low dose MPC injection met the pre-specified treatment success criteria at 6 months compared with only 20 percent and 30 percent of the patients in the two control arms who received hyaluronic acid and saline
This discovery appears to challenge the practice of injecting hyaluronic acid alone into a patient's joints.
The main dermatological application of hyaluronic acid is growing soft tissues through intradermic injections to correct skin problems caused by wrinkles, scars, lip enlargement or other defects (MANNA et al.
Localization of epidermal hyaluronic acid using the hyaluronate binding region of cartilage proteoglycan as a specific probe.
In the 1990s, the first available hyaluronic acid (abbreviated as "HA") products became available as injectable agents for osteoarthritis of the knee.
Tri-Hyaluronic Acid Complex: An industry first, Tri-Hyaluronic Acid Complex is a unique blend of three Hyaluronic Acid technologies that work at multiple levels in the skin to help replenish, rebuild and sustain the ideal moist environment for more lineless, youthful looking skin.
The research from McMaster, recently published in the journal Biomaterials, shows that hyaluronic acid can be entrapped in existing contact lens material without affecting optical properties.