hyaluronidase


Also found in: Dictionary, Thesaurus, Medical, Wikipedia.
Related to hyaluronidase: hyaluronic acid

Hyaluronidase

Any one of a family of enzymes, also known as hyaluronate lyases or spreading factors, produced by mammals, reptiles, insects, and bacteria, which catalyze the breakdown of hyaluronic acid. Some hyaluronidases also attack other similar polysaccharides. Since all liquefy the polysaccharide gel which fills the tissue spaces, they effectively accelerate diffusion so that injected, dissolved, or particulate matter (bacteria, viruses, toxins, or pigments) can diffuse through a larger volume of tissue. See Hyaluronic acid

The biological importance of the enzyme depends upon its source. That found in the culture filtrates of many strains of virulent bacteria permits the microorganisms to gain access to a larger volume of the host's tissue and, hence, to additional nutriment. That found in the venom of certain snakes and bees permits the toxin to produce more extensive damage to the victim. See Enzyme

hyaluronidase

[‚hī·ə·lu̇′rän·ə‚dās]
(biochemistry)
Any one of a family of enzymes which catalyze the breakdown of hyaluronic acid. Also known as hyaluronate lyase; spreading factor.
References in periodicals archive ?
The only complication of note in this study was irregularity of the eyelid skin for the patient with repeat injections; this was corrected with hyaluronidase injections.
Hyaluronidase is part of extracellular bacterial structure that degrade hyaluronic acid , hyaluronidases event by [BETA] elimination of the [BETA]-1,4 glycosidic bond in hyaluronic acid[5].
Paul AS, Sochart DH Improving the results of ganglion aspiration by the use of hyaluronidase, J Hand Surg [Br] 1997; 22:219-221
Using the transglycosylation activity of hyaluronidase, it has been confirmed that both natural and unnatural GAG chains can be synthesized.
0), Dimethyl sulphoxide (DMSO), Dulbecco's modified eagle's media (DMEM), fetal bovine serum (FBS), penicillin, streptomycin, trypsin-EDTA, 344,5-dimethylthiazo1-2-y1)-2,5-diphenyltetrazolium bromide (MTT), 2,7-dichlorodihydrofluorescein diacetate (DCHF-DA), propidium iodide, ribonuclease A (RNase A), hyaluronic acid (HA), hyaluronidase (ENZ) were purchased from Sigma Aldrich Chemicals Private Limited (St.
Hyaluronidase products approved by the United States Food and Drug Administration (FDA) have included those derived from bovine (AMPHADASE, [R] Amphastar Pharmaceuticals, Inc, Rancho Cucamonga, CA) and ovine(Vitrase, [R] ISTAPharmaceuticals, Inc.
Purification and properties of hyaluronidase from Hippasa partita (funnel web spider) venom.
Halozyme has granted ViroPharma an exclusive worldwide license to use Halozyme's proprietary Enhanze technology, a proprietary drug delivery platform using Halozyme's recombinant human hyaluronidase enzyme (rHuPH20) technology in combination with a C1 esterase inhibitor.
Local injection of hyaluronidase mixed with hydrocortisone acetate had been used at our centre for the last 20 ys with satisfactory clinical results and without any significant side effects.
Hyaluronidase enzyme play an important role in the process of fertilization (McRorie and Williams, 1974) and its untimely leakage due to cellular injury is detrimental for the fertilization process.
The incorporation of animal-derived hyaluronidase into the anesthetic protocol for ophthalmic surgery has historically been shown to increase the speed of anesthetic onset, enhance the intensity and decrease the volume of drug required," said Scott Greenbaum M.