hyaluronidase


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Related to hyaluronidase: hyaluronic acid

Hyaluronidase

Any one of a family of enzymes, also known as hyaluronate lyases or spreading factors, produced by mammals, reptiles, insects, and bacteria, which catalyze the breakdown of hyaluronic acid. Some hyaluronidases also attack other similar polysaccharides. Since all liquefy the polysaccharide gel which fills the tissue spaces, they effectively accelerate diffusion so that injected, dissolved, or particulate matter (bacteria, viruses, toxins, or pigments) can diffuse through a larger volume of tissue. See Hyaluronic acid

The biological importance of the enzyme depends upon its source. That found in the culture filtrates of many strains of virulent bacteria permits the microorganisms to gain access to a larger volume of the host's tissue and, hence, to additional nutriment. That found in the venom of certain snakes and bees permits the toxin to produce more extensive damage to the victim. See Enzyme

McGraw-Hill Concise Encyclopedia of Bioscience. © 2002 by The McGraw-Hill Companies, Inc.

hyaluronidase

[‚hī·ə·lu̇′rän·ə‚dās]
(biochemistry)
Any one of a family of enzymes which catalyze the breakdown of hyaluronic acid. Also known as hyaluronate lyase; spreading factor.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
Efficacy of holmium laser urethrotomy and intralesional injection of Santosh PGI tetra-inject (Triamcinolone, Mitomycin C, Hyaluronidase and N-acetyl cysteine) on the outcome of urethral strictures.
The study, conducted during 2013-2014, analyzed the impact of various small doses of hyaluronidase on two types of fillers that had been administered into the upper inner arms of nine women (seven white, two black; mean age, 46 years).
The researchers found that at four weeks and four months there were significant differences in physician rater assessment for visual detection and palpability between saline and hyaluronidase; this was mirrored by participant self-assessment at four weeks and four months.
Hyaluronan can be distinguished from other materials by the disappearance of the stain after hyaluronidase digestion.
The only complication of note in this study was irregularity of the eyelid skin for the patient with repeat injections; this was corrected with hyaluronidase injections.
KEYWORDS : Hyaluronidase, killing Bacteria, Klebsiella pneumoniae, Staphylococcus aureus
Pham et al., "Urinaryhyaluronic acid and hyaluronidase: markers for bladder cancer detection and evaluation of grade," The Journal of Urology, vol.
Chondroitinase however had no significant effect on liver enzyme release (not shown); hyaluronidase, heparanase, and ferritin-concanavalin A complex elicited significant effects (Figures 2-4).
Hyaluronidase inhibiton assay was performed according to the methods described by Lee & Choi (1999) and Sahasrabudhe & Deodhar (2010) with some modifications (18-20).
Patients received 1:1 mixture of 2% lidocaine and 0.5% bupivacaine with 50 IU/mL of hyaluronidase and adrenaline 1 in 4,00,000.
In the present study, hyaluronidase loaded PLGA was prepared using double emulsion technique.