The [sup.13]C NMR spectra of 3 and 8-11 contain most low-field singlet signals with chemical shift values 175.5-183.2 ppm and 156.5-162.3 ppm assigned to the carbon atoms of the hydantoin
cycle; carbon signals of the piperidine ring of 3 and 10 correspond to triplets at 48.9 and 56.0 ppm (C-7, C-9); 30.1 and 36.1 ppm (C-6, C-10).
Some familiar chemicals that may give consumers pause, such as formaldehyde, often are not ingredients at all, but rather are released by other, more obscure ingredients, such as DMDM hydantoin
. And constituents of fragrance and flavor, which include several controversial ingredients, can be considered "trade secrets" and exempt from disclosure on labels.
 Nonstandard abbreviations: PTMDPs, nonenzymatic posttranslational modifications derived products; Hb [A.sub.1c], hemoglobin [A.sub.1c]; CRF, chronic renal failure; CDPs, carbamylation-derived products; EPO, erythropoietin; cLDL, carbamylated LDL; cHb, carbamylated hemoglobin; VH, valine hydantoin
To unambiguously prove that the OH group was consumed by the NCO, the product was heated overnight at 60[degrees]C in an open scintillation vial and monitored for the formation of hydantoin
The first-generation AEDs known to cause birth defects and other developmental toxicities include the hydantoins
(ethotoin [Peganone], fosphenytoin [Cerebyx], mephenytoin [Mesantoin], and phenytoin [Dilantin]), phenobarbital, primidone (Mysoline), carbamazepine (Tegretol), and valproic acid derivatives (Depakene, Depakote).
Only 5%-10% of women taking anticonvulsants during pregnancy develop fetal hydantoin
* Lose FORMALDEHYDE: The following ingredients may contain, release or break down into formaldehyde: 2-bromo-2-nitropropane1,3-diol; diazolidinyl urea; DMDM hydantoin
; imidazolidinyl urea; quaternium 15.
The effects of phenytoin on rat development: an animal model system for fetal hydantoin
Alternatively or additionally, the Michael donor contains beta-ketoamide, enamine carboxylate, enamine amide, pyrazolone, isoxazolone, hydantoin
, rhodanine, thio-substituted unsaturated ester, thio-substituted lactone or phosphonite or phosphinite ester groups.
The following are formaldehyde derived: Imidazolidinyl urea, diazolidinyl urea, 2-bromo-2-nitropropane-1, 3-diol, DMDM hydantoin
and quaternium 15
dev.) (MPa) 1,3 dichloro-5,5 dimethyl 2.69 (0.15) hydantoin
n-bromomethyl phthalimide 2.27 (0.13) n-iodo succinimide 2.42 (0.072) n-chloromethyl phthalimide 1.88 (0.099) n-bromo phthalimide 2.00 (0.17) l-(cis-3 dichloroallyl) 1.11 (0.19) 3,5,7,triaza-1-azonia adamantane chloride
When she specifically asked her physician about the risks of these medications during pregnancy, she was not told about the possibility of fetal hydantoin
syndrome, which could result from those medications.