To examine the origin of brain-type Tf, we analyzed the CSF of patients with hydranencephaly
, a congenital malformation of the brain.
Common cephalic disorders include anencephaly, colpocephaly, holoprosencephaly, ethmocephaly, hydranencephaly
, iniencephaly, lissencephaly, megalencephal, microcephaly, porencephaly, and schizencephaly.
The following brain anomalies have also been observed in microcephalic fetuses: hydrops fetalis and hydranencephaly
. Both anomalies led to pregnancy termination.
A 22-month-old baby suffering from a rare brain condition was left with a disfigured skull, looking like "devil horns," after undergoing a surgery to reduce pressure on his brain. Clyne Solano of Phillipines, was born with a condition called hydranencephaly
- where the brain size is small and the remaining cranial cavity is filled with cerebrospinal fluid.
* Selected congenital brain anomalies: intracranial calcifications; cerebral atrophy; abnormal cortical formation (e.g., polymicrogyria, lissencephaly, pachygyria, schizencephaly, gray matter heterotopia); corpus callosum abnormalities; cerebellar abnormalities; porencephaly; hydranencephaly
In cases of hydranencephaly
there is complete loss of brain parenchyma leading to a large fluid filled cavity within the brain that is covered by a pial-glial membrane (Barkovich and Norman, 1989; Stevenson et al., 2001).
Neuroepidemiology of Porencephaly, Schizencephaly, and Hydranencephaly
in Miyagi Prefecture, Japan.
Khouri et al., "Zika virus infection and stillbirths: a case of hydrops fetalis, hydranencephaly
and fetal demise," PLoS Neglected Tropical Diseases, vol.
Takahashi et al., "Neuroepidemiology of Porencephaly, Schizencephaly, and Hydranencephaly
in Miyagi Prefecture, Japan," Pediatric Neurology, vol.
Subsequent ultrasound evaluations performed at 26 and 30 weeks' gestation revealed microcephaly, hydranencephaly
and minimal residual cortical tissue, intracranial calcifications, and destruction of the posterior fossa.
The fetal injuries that result from infections with these viruses are most often described as hydranencephaly
, porencephaly, cerebellar hypoplasia, retinal dysplasia, microcephaly and arthrogryposis of neurogenic nature, among others (OBERST, 1993).