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(hī'drəkôr`tĭzōn'), another name for the steroid hormone cortisolcortisol
or hydrocortisone,
steroid hormone that in humans is the major circulating hormone of the cortex, or outer layer, of the adrenal gland. Like cortisone, cortisol is classed as a glucocorticoid; it stimulates liver glycogen formation while it decreases the rate
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, more especially used to refer to preparations of this hormone used medicinally. Hydrocortisone, introduced in 1952, is more potent than cortisonecortisone
, steroid hormone whose main physiological effect is on carbohydrate metabolism. It is synthesized from cholesterol in the outer layer, or cortex, of the adrenal gland under the stimulation of adrenocorticotropic hormone (ACTH).
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 with respect to medicinal metabolic and anti-inflammatory effects. Like cortisone, it is used to treat Addison's diseaseAddison's disease
[for Thomas Addison], progressive disease brought about by atrophy of the outer layer, or cortex, of the adrenal gland; it is also called chronic adrenocortical insufficiency.
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, inflammatory and rheumatoid diseases, and allergies. Low-potency hydrocortisone, available over the counter, is used to treat skin irritations. See also corticosteroid drugcorticosteroid drug
, any one of several synthetic or naturally occurring substances with the general chemical structure of steroids. They are used therapeutically to mimic or augment the effects of the naturally occurring corticosteroids, which are produced in the cortex of the
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; steroidssteroids,
class of lipids having a particular molecular ring structure called the cyclopentanoperhydro-phenanthrene ring system. Steroids differ from one another in the structure of various side chains and additional rings. Steroids are common in both plants and animals.
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The Columbia Electronic Encyclopedia™ Copyright © 2013, Columbia University Press. Licensed from Columbia University Press. All rights reserved. www.cc.columbia.edu/cu/cup/
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.



(17-hydroxycorticosterone, cortisol), one of the glucocorticoids; a hormone formed in the adrenal cortex and predominantly regulating carbohydrate metabolism. The human adrenal glands secrete from 5 to 30 mg of hydrocortisone per day, although formation of hydrocortisone may increase five times under conditions of stress or upon introduction of adrenocorticotropic hormone.

Hydrocortisone is used in medical practice as a hormonal preparation that exerts an anti-inflammatory and antiallergic effect. Hydrocortisone (and hydrocortisone acetate in the form of a suspension) is prescribed for the treatment of rheumatism, bronchial asthma, leukemia, and endocrine and other diseases; it is used locally (most often in the form of a cream) for eczema, neurodermatitis, and eye diseases.

The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.


C21H30O5 The generic name for 17-hydroxycorticosterone; an adrenocortical steroid occurring naturally and prepared synthetically; its effects are similar to cortisone, but it is more active. Also known as cortisol.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
Lupin's Hydrocortisone Valerate Cream USP, 0.2%, is the generic version of Westcort Cream, 0.2%, of Sun Pharmaceutical Industries, Inc.
Rescue analgesic was required in only 8 out of 30 in the Bupivacaine group where as 19 out of 30 in Hydrocortisone group.
Hydrocortisone products account for roughly half the sales in the anti-itch category, points out Ascher assistant marketing manager Ben Knopke, but growth and innovation are usually realized with non-hydrocortisone products like the company's Itch-X gel.
Caption: Figure 7: Dissolution profiles of film-coated wet granulation HWSP-based and CASP-based hydrocortisone matrix tablet formulations (~25%w/w) in simulated gastrointestinal fluids (pH 1.2, 2h; pH 6.8, 3 h; pH 7.4, 6 h) (mean [+ or -] SEM., n = 3).
Stanhope, "Hydrocortisone replacement therapy in children and adolescents with hypopituitarism," Clinical Endocrinology, vol.
They were randomly assigned, in a double-blind manner, to three treatment groups- aqueous extract of edible dried fig fruit, Hydrocortisone 1.0 per cent and base cream as a placebo.
Pooley started the patient on 20 mgs of hydrocortisone with divided doses.
With 250,000 Americans perishing each year from sepsis, (1) we eagerly await results from clinical trials that will study the effects of intravenous vitamin C, thiamine and hydrocortisone on large numbers of sepsis patients.
US patent 10,166,194, entitled 'Hydrocortisone Controlled Release Formulation', is a patent claiming a method of treatment for adrenal dysfunction, including the diseases congenital adrenal hyperplasia (CAH) and adrenal insufficiency (AI) that delivers hydrocortisone in accordance with a circadian rhythm.
An ACTH stimulation test to confirm the CAH diagnosis was done after stopping hydrocortisone for 24 hours.
Hydrocortisone is a naturally occurring corticosteroid hormone secreted by the adrenal cortex and released during times of stress.

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