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(hī'drəkôr`tĭzōn'), another name for the steroid hormone cortisolcortisol
or hydrocortisone,
steroid hormone that in humans is the major circulating hormone of the cortex, or outer layer, of the adrenal gland. Like cortisone, cortisol is classed as a glucocorticoid; it stimulates liver glycogen formation while it decreases the rate
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, more especially used to refer to preparations of this hormone used medicinally. Hydrocortisone, introduced in 1952, is more potent than cortisonecortisone
, steroid hormone whose main physiological effect is on carbohydrate metabolism. It is synthesized from cholesterol in the outer layer, or cortex, of the adrenal gland under the stimulation of adrenocorticotropic hormone (ACTH).
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 with respect to medicinal metabolic and anti-inflammatory effects. Like cortisone, it is used to treat Addison's diseaseAddison's disease
[for Thomas Addison], progressive disease brought about by atrophy of the outer layer, or cortex, of the adrenal gland; it is also called chronic adrenocortical insufficiency.
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, inflammatory and rheumatoid diseases, and allergies. Low-potency hydrocortisone, available over the counter, is used to treat skin irritations. See also corticosteroid drugcorticosteroid drug
, any one of several synthetic or naturally occurring substances with the general chemical structure of steroids. They are used therapeutically to mimic or augment the effects of the naturally occurring corticosteroids, which are produced in the cortex of the
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; steroidssteroids,
class of lipids having a particular molecular ring structure called the cyclopentanoperhydro-phenanthrene ring system. Steroids differ from one another in the structure of various side chains and additional rings. Steroids are common in both plants and animals.
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(17-hydroxycorticosterone, cortisol), one of the glucocorticoids; a hormone formed in the adrenal cortex and predominantly regulating carbohydrate metabolism. The human adrenal glands secrete from 5 to 30 mg of hydrocortisone per day, although formation of hydrocortisone may increase five times under conditions of stress or upon introduction of adrenocorticotropic hormone.

Hydrocortisone is used in medical practice as a hormonal preparation that exerts an anti-inflammatory and antiallergic effect. Hydrocortisone (and hydrocortisone acetate in the form of a suspension) is prescribed for the treatment of rheumatism, bronchial asthma, leukemia, and endocrine and other diseases; it is used locally (most often in the form of a cream) for eczema, neurodermatitis, and eye diseases.


C21H30O5 The generic name for 17-hydroxycorticosterone; an adrenocortical steroid occurring naturally and prepared synthetically; its effects are similar to cortisone, but it is more active. Also known as cortisol.
References in periodicals archive ?
Comment: This study demonstrates that topical application of human breast milk is as effective as topical hydrocortisone for the treatment for diaper rash in infants.
Initially, I put the onus on him to see if there was a body balm with 1% hydrocortisone in a tube and what the patent status was.
Chronocort is a modified release therapy that delivers hydrocortisone in a manner that mimics the body's normal circadian rhythm (the body's natural 24-hour hormone cycle).
There is a clear need in the treatment of AI for an oral hydrocortisone replacement therapy that better resembles the body's natural cortisol production, that can be given once a day and that may improve patients' metabolic status and compliance to treatment," said Dr Anna G Nilsson, Principal Investigator for all Plenadren studies and Consultant in Endocrinology at the Sahlgrenska University Hospital, Goteborg, Sweden.
In order to test the different stress hormones, the cognition psychologists used three substances - a placebo, the stress hormone hydrocortisone and yohimbine, which ensures that the stress hormone noradrenaline stays active longer.
We used LC-MS/MS analysis (2) and our previously published algorithm (4) to evaluate whether the patient might have contaminated samples with topical hydrocortisone during collection.
Our clinical impression that neomycin/polymyxin B/ hydrocortisone drops do not pose an ototoxicity risk in humans when used responsibly is clearly in conflict with findings from studies of animal models.
Nothing else worked, and secondary analyses suggested hydrocortisone might be harmful.
If true, then the use of a regimen of 20 mg of hydrocortisone twice daily for ten days, initiated within 12 hours of hospital admission following a traumatic event might keep patients from developing the disorder altogether.
The others in Group A are fludrocortisone acetate, hydrocortisone acetate, and--importantly--methylpred-nisolone and prednisone.
In the study, 499 adults with septic shock that had its onset within 72 hours were randomly assigned to receive an 11-day course of either placebo or hydrocortisone at a dose of 50 milligrams (mg.
However hydrocortisone treatment was able to significantly (p [less than or equal to] 0.

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