hydroxamic acid


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hydroxamic acid

[¦hī‚dräk¦sam·ik ′as·əd]
(organic chemistry)
An organic compound that contains the group ‒C(=O)NHOH.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
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Cardiomyogenic Differentiation of Human Dental Follicle-derived Stem Cells by Suberoylanilide Hydroxamic Acid and Their In Vivo Homing Property.
A number of HDACIs have been identified and some are under clinical trial with a hydroxamic acid scaffold for the treatment of various types of cancer.
The combination of the histone deacetylase (HDAC) inhibitor suberanilo hydroxamic acid (vorinostat) with chemotherapeutics and/or radiation have shown much positive results.
Kharya, 2, 5-Disubstituted-1, 3, 4-oxadiazoles/thiadiazole as Surface Recognition Moiety: Design and Synthesis of Novel Hydroxamic Acid Based Histone Deacetylase Inhibitors.
Raipur (Chhattisgarh) [India], July 14 ( ANI ): Mamata Tripathi, a researcher from Raipur, has claimed that N-aryl Hydroxamic Acid can be helpful in curing cancer.
The hydroxamic acid group (--NH --OH) is well known for its ability to form a stable chelates with various heavy metal ions.
Mechanism of ligand substitution on high-spin iron(III) by hydroxamic acid chelators.
Pilz et al., "Comparative evaluation of the treatment efficacy of suberoylanilide hydroxamic acid (SAHA) and paclitaxel in ovarian cancer cell lines and primary ovarian cancer cells from patients," BMC Cancer, vol.
Vorinostat and belinostat are hydroxamic acid derivatives that inhibit class I and II HDACs [11,12].
Phase 2 trial of oral vorinostat (suberoylanilide hydroxamic acid, SAHA) for refractory cutaneous T-cell lymphoma (CTCL).