hydroxyurea


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hydroxyurea

[‚hī¦dräk·sē·yu̇′rē·ə]
(pharmacology)
HONHCONH2 Needlelike crystals with a melting point of 133-136°C; used as an antineoplastic agent. Also known as hydroxycarbamide.
References in periodicals archive ?
"This is risky as medicines like hydroxyurea are dangerous, even to touch.
Hydroxyurea, as shown in Fig.1, is non-planar drug with OH, N[H.sub.2], CO and NH groups.
Romidepsin (stock solution: 1 mM in DMSO), entinostat (stock solution: 5 mM in DMSO), and irinotecan (stock solution: 10 mM in DMSO) were from Selleckchem; hydroxyurea (stock solution: 100 mM in PBS) was from Sigma-Aldrich; and imatinib (stock solution: 1 mM in DMSO) and marbostat-100 (stock solution: 10 mM in DMSO) were synthesized by A.
The association between sickling crises, anemia, intake of folate and hydroxyurea were considered to be statistically significant for SS and ST patients (p<0.05).
Allopurinol 300mg daily and hydroxyurea 2g daily were commenced immediately to ensure cytoreduction.
One would assume that insurance companies would be less restrictive if they were paying $1,400 per year for generic glutamine (an amount only slightly more than the cost of hydroxyurea), rather than $28,000 per year for Endari.
The patient was diagnosed with JAK2 V617F mutationpositive polycythemia vera 22 years ago and was maintained on hydroxyurea and darbepoetin alfa.
Bassukas, "An in vivo study on the synchronizing effect of hydroxyurea," Experimental Cell Research, vol.
The potential role of Hb-induced tyrosine radicals in generating Hb-HDL cross-links was tested by studying the effect of different concentrations (10-400 nM) of hydroxyurea on HDL Hb cross-linking.
Early intervention, when MA is present, using antiproteinuric measures such as blockade of the renin angiotensin system or use of hydroxyurea, may slow the progression to overt proteinuria and advanced chronic kidney disease (CKD) [6].
Hydroxyurea is a chemotherapeutic agent that increases the production of fetal hemoglobin and decreases SCD-related complications.
Hydroxyurea, interferon alfa, and peginterferon alfa have been shown to be effective for the prevention of thrombotic complications in patients with PV.