Carrageenan is an inflammatory agent that is widely employed in experimental models of edema and hyperalgesia
, especially in studies involving non-steroidal anti-inflammatory drugs (NSAIDs).
Although generally considered as an analgesic or adjuvant, however, some studies have reported an opposite effect of magnesium: thus, intravenous administration of MgS[O.sub.4] in local capsaicin-induced thermal hyperalgesia
has been demonstrated to increase pain intensity (12).
By blocking glutamate reuptake and increasing it in the synapse, ketamine "resets the hyperalgesia
hyper-excitatory pathway that's been stuck in this 'on' position," Dr.
For the examination of thermal hyperalgesia
, the mouse was placed on a 2-mm-thick glass surface covered with a Plexiglass box.
Characterization of the effects of gabapentin and 3isobutyl-gamma-aminobutyric acid on substance P-induced thermal hyperalgesia
. Anesthesiology 1998; 88(1): 196-205.
His symptoms of distal limb hyperalgesia
We evaluated the tumor growth and measured the induced cold allodynia and mechanical and thermal hyperalgesia
as indicators of pain development.
As nerve injury leads to mechanical allodynia and thermal hyperalgesia
, animal pain behaviors were analyzed.
The soluble mediators released by activated MCs, particularly proinflammatory mediators and cytokines such as tryptase and interleukin-1[beta] (IL-1[beta]), contribute to visceral hyperalgesia
The study, published in Neuroscience in December 2016, found that fibromyalgia patients have a heightened sensitivity to pain (hyperalgesia
) when presented with stimuli classified as "normal," compared to their "healthy" counterparts.
Women with longer incisions (more than 17 cm or about 6.5 inches) were also more likely to report higher pain scores, including wound hyperalgesia
, or an increased sensitivity to pain around the surgical incision.