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The results showed that FKN-neutralizing antibody significantly lowered CCI-induced thermal hyperalgesia and mechanical allodynia after treatment, while it had no effect on sham-operated rats (Figure 5).
The altered neuronal activity, also known as neuronal plasticity, is collectively believed to constitute the foundation of rheumatic pain and is characterized by hyperalgesia, an elevated noxious response to painful stimuli, and allodynia, a painful response to a normally mild and harmless stimulus.
All patients presented with sensory or autonomic symptoms, which included disturbance of pinprick sensation and temperature sensation, allodynia, hyperalgesia, numbness, coldness, tightness, burning sensation, tingling sensation, bedsheet intolerance, restless legs, sensation of walking on sand or pebbles, muscle cramps, palpitations, hot flushes, hyper/hypohidrosis, skin discoloration, difficulty in urination, constipation/diarrhea, sexual dysfunction, or sicca syndrome.
8] Hence, proteins mediating mechanical hyperalgesia in TRP ion channel have increasingly attracted the concern of academics.
It has recently been reported that P2X4R are essential for morphine-induced hyperalgesia (MIH) through a P2X4R-BDNF-KCC2 disinhibition cascade in microglia and dorsal horn neurons.
However, neither the SBE prevented the thermal hyperalgesia in hot-plate test, nor the naloxone reversed the SBE antinociceptive effect in capsaicin test.
So, the pain and hyperalgesia in the incision area is reduced to a greater proportion than referred pain of hysterectomy.
Opioid-induced hyperalgesia can cause patients to assess their baseline pain incorrectly," Holbert says.
GlobalData's clinical trial report, "Hyperalgesia Global Clinical Trials Review, H1, 2016" provides an overview of Hyperalgesia clinical trials scenario.
USPRwire, Wed Apr 06 2016] Global Markets Direct's, 'Hyperalgesia - Pipeline Review, H1 2016', provides an overview of the Hyperalgesia pipeline landscape.
After a 3-week waiting period, the second hot-plate test measurements were conducted to check whether hyperalgesia secondary to diabetic neuropathy had developed.