hypercorticism


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hypercorticism

[‚hī·pər′kȯrd·ə‚siz·əm]
(medicine)
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(5) The absence of endocrinological disorders: hypothyroidism, hypercorticism, syndrome of the polycystic ovaria
For instance, a short height of a child that is potentially related to hypercorticism needs supplementary investigations including a pituitary scan and finding an ACTH (Adrenocoticotropic Hormone) secreting tumour is not an incidentaloma.15 As age distribution pattern, adrenal and pituitary sites seem more frequent in elderly than in youth.9,16 Most frequent adrenals are involved in the sixth and seventh decades.9,16 A particular attention is needed to an adrenal mass in children and adolescence due to high malignancy risk.9,16 General approach of incidentalomas's management involves a multidisciplinary team.
Biochemical Findings Non-Functional/Biochemically Inert Lesion 26 Hypercorticism 8 Elevated serum cortisol, 24-hour urine cortisol Hyperaldosteronism Hypokalaemia (<3.5 mEq/L) 2 Increased plasma aldosterone (>15 ng/dL) Phaeochromocytoma 4 Elevated 24-hour urine catecholamines Hyperandrogenism 3 Elevated DHEA/17 ketosteroids Table 3.
The underlying mechanisms for the observed shrinkage are not well understood; however, it might be due to the lactation-associated hypercorticism, as studies in male rats revealed dendritic atrophy in hippocampal pyramidal cells after chronic stress-induced elevation of glucocorticoids [138].