Cushing's syndrome

(redirected from hypercortisolism)
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Cushing's syndrome

[′ku̇sh·iŋz ‚sin‚drōm]
(medicine)
A complex of symptoms including facial and truncal obesity, hypertension, edema, and osteoporosis, resulting from oversecretion of adrenocortical hormones.
References in periodicals archive ?
In EAS, hypercortisolism unmasks the mineralocorticoid action of cortisol due to saturation of 11betahydroxysteroid dehydrogenase, leading to renal sodium retention.
In both groups, compared to baseline evaluation, after hypercortisolism resolution we found a significant reduction of office systolic blood pressure (SBP) (group A 143 [+ or -] 20 mmHg vs.
Additionally, wound healing delay may occur in some pregnancies complicated with hypercortisolism. Perinatal complications include fetal growth restriction, preterm delivery, stillbirth, and neonatal death.
The sample included 39 patients with CS (16 patients with active hypercortisolism and 23 patients in remission) and 39 healthy controls, which were matched for sex, age ([+ or -]3 years), and years of education ([+ or -]3 years).
Pronounced and sustained central hypernoradrenergic function in major depression with melancholic features: Relation to hypercortisolism and corticotropin-releasing hormone.
Patients with following conditions were excluded from the study: obstructive airways disease other than COPD (bronchiectasis, cystic fibrosis or fibrosis due to tuberculosis), smoking within the last one month, patients on steroids, known thyroid diseases, hypercortisolism, diabetes mellitus, hyperlipidemias, ischemic heart disease, non-pulmonary infective diseases, renal, cardiac or hepatic failures, autoimmune diseases and malignancies.
Potential subjects were excluded if they had hypertension, coronary artery disease, congestive heart failure, systemic rheumatic disease, diabetes mellitus, thyroiditis, renal disease, hypercortisolism, or hyperprolactinemia; had used oral contraceptives, other hormone treatments, or any kind of medicine in the previous 3 months; were pregnant or breastfeeding; active smokers; or chronic alcohol consumers.
The most common signs of hypercortisolism are weight gain, short in stature, muscle weakness, altered mood, delayed sexual development, thin skin, acne, and acanthosis nigricans.
McCune-Albright Syndrome (MAS) is a considerably rare syndrome in which hyperthyroidism, hyperparathyroidism, hypercortisolism, excessive secretion of growth hormone and prolactin may be observed in addition to the three classical findings (1, 2).
This indicates that the effect of previous hypercortisolism on cognitive function and generally on the central nervous system is irreversible.