hypergammaglobulinemia


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hypergammaglobulinemia

[¦hī·pər‚gam·ə¦gläb·yə·lə′nē·mē·ə]
(medicine)
Increased blood levels of gamma globulin, usually associated with hepatic disease.
References in periodicals archive ?
Specifically, the erythrocyte sedimentation rate (ESR) is elevated in nearly 90% of RDD cases and polyclonal hypergammaglobulinemia is present in approximately 80-90% of cases according to several studies [1, 4-8].
The disease typically manifests as painless, massive lymphadenopathy that frequently affects cervical lymph nodes and is accompanied by fever, leukocytosis, increased erythrocyte sedimentation rate, and hypergammaglobulinemia [2].
In mice, transgenic expression of IL-6 induces a syndrome similar to CD, with lymphadenopathy, splenomegaly, anemia, plasma cell infiltration of lymphoid tissues, and hypergammaglobulinemia [11].
Its main manifestations include hypergammaglobulinemia, immune complex formation, and activation of complement system.
Effect of highly active antiretroviral therapy (HAART) on hypergammaglobulinemia in HIV infected patients [article in Japanese; English abstract].
Polyclonal B-cell lymphocytosis and hypergammaglobulinemia in patients with Gaucher disease.
Hypergammaglobulinemia in the pediatric population as a marker for underlying autoimmune disease: a retrospective cohort study.
The polyclonal activation of B cells is a characteristic of PCM that frequently results in hypergammaglobulinemia (4).
Background/Aims: The significance of hypergammaglobulinemia as a phenotypic feature of inflammatory bowel disease is unknown.
[3] first reported a case about nonalcoholic chronic pancreatitis accompanied by hypergammaglobulinemia and predicted its association with an autoimmune process.
In addition, they noted that the diseases were characterized by (1) autoantibodies, (2) hypergammaglobulinemia, (3) tissue deposition of immune complexes, (4) lymphocytic and plasma cell accumulation in the affected tissues, (5) the therapeutic benefit from corticosteroids, and (6) the overlap of differing autoimmune manifestations in the same patient.
In particular, a case has been reported with features mimicking autoimmune hepatitis, with abnormal liver histology and elevated levels of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, gamma glutamyl-transferase and bilirubin, associated with hypergammaglobulinemia, and the transient presence of anti-smooth-muscle antibodies (ASMA) and anti-neutrophil cytoplasmic antibodies (ANCA) [8].