Serum biochemical and hematologic tests showed hyperuricemia, hyperphosphatemia, an increased level of aspartate aminotransferase, hyperglobulinemia
, nonregenerative anemia, and severe leukocytosis in comparison with physiologic reference ranges for these conditions (12).
The multicentric plasmocytic subtypes may present with the "B" symptoms encountered in lymphomas with polyclonal hyperglobulinemia
, the pathophysiology of CD residing in an excessive proliferation of B lymphocytes and plasma cells) .
The present investigation exhibited hypoglycemia, higher level of AST, hypoproteinemia, hypoalbuminemia, hyperglobulinemia
and increased values of creatinine and BUN in Babesia infected animals.
Results of plasma biochemical analysis indicated a low albumimglobulin ratio of 0.5 (reference interval, 0.77-1.19), an elevated creatinine kinase concentration of 1410 U/dL (reference interval, 293-1135 U/dL), hypoalbuminemia at 1.05 g/dL (reference interval, 1.31-1.83 g/dL), and hyperglobulinemia
at 2.1 g/dL (reference interval, 0.28-0.44 g/dL).
Dogs with an exacerbated humoral response and hyperglobulinemia
can have deposition of circulating immune complexes at the glomerular level, inducing inflammatory changes that lead to glomerular damage [4, 6-8].
Further, there is a correlation between the degree of serum hypoalbuminemia and hyperglobulinemia
A serum biochemical panel showed new hypoalbuminemia (16 g/L; reference interval: 27 to 39 g/L) and continued but stable hyperglobulinemia
(46 g/L; reference interval: 24 to 40 g/L).
Hallmark features of AIH include hyperglobulinemia
, circulating autoantibodies, and histological features consistent with the chronic necroinflammatory state .
(%) Increased ALT 14 (33.3) 4 (9.5) 0.022 Increased AST 12 (28.57) 3 (7.1) 0.029 Increased Bilirubin 3 (7.14) 3 (7.1) 1.00 Reversed A/G ratio 10 (23.8) 2 (4.7) 0.036 (Hyperglobulinemia
) Increased Prothrombin time 0 0 -- HBsAg 1 (2.38) 2 (11.9) 0.61 Anti HCV antibodies 8 (19.04) 1 (2.3) 0.029 Table 2: Clinical and Laboratory Results in Eight Patients with LP and HCV Antibodies Sl.
Earlier studies also have reported hyperglobulinemia
and hypoalbuminemia in camels which could be due to centrilobular degeneration and hepatic injuries associated with hypoxia (Chaudhary and Iqbal, 2000; Ahmad et al., 2004).
(6) Systemic haematological abnormalities such as hyperglobulinemia
and iron refractory anaemia have been documented in some patients with LPM, believed by some to be due to the plasma cell infiltrate.
Hematologic findings were very similar to a previous study that described also monocytosis and hyperglobulinemia
in a cutaneous nocardiosis in a dog (GOLYNSKY et al., 2006).