hyperinsulinism


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Related to hyperinsulinism: Hyperinsulinemia

hyperinsulinism,

presence in the system of an above-normal amount of insulininsulin,
hormone secreted by the β cells of the islets of Langerhans, specific groups of cells in the pancreas. Insufficiency of insulin in the body results in diabetes. Insulin was one of the first products to be manufactured using genetic engineering.
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, the substance secreted by the pancreaspancreas
, glandular organ that secretes digestive enzymes and hormones. In humans, the pancreas is a yellowish organ about 7 in. (17.8 cm) long and 1.5 in. (3.8 cm) wide. It lies beneath the stomach and is connected to the small intestine at the duodenum (see digestive system).
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 and needed by the body to utilize sugar. An increased amount of insulin in the body results in below-normal amounts of sugar in the system, giving rise to such symptoms as headache, dizziness, weakness, and emotional instability. In severe cases there may be convulsions, coma, and death. The cause of oversecretion of insulin may be organic, i.e., a tumor of the pancreas, impaired liver function, or endocrine disorders, or it may be functional, e.g., unusual muscular exertion, pregnancy, or lactation. In diabetics, hyperinsulinism is known as insulin shock and may occur from overdosage with insulin in the course of treatment. Where there is some organic cause for hyperinsulinism, surgery may be required to eliminate it. Functional hyperinsulinism and insulin shock are treated by dietary measures designed to bring the insulin-sugar ratio into better balance.

hyperinsulinism

[‚hī·pər′in·sə·lə‚niz·əm]
(medicine)
Condition caused by abnormally high levels of insulin in the blood.
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References in periodicals archive ?
(9,14,15) Finally, our experiment dealing with the annulment of hyperinsulinism and hypoglycemia by doxepin (a serotonin uptake inhibitor) in a large number of patients (16) led us to explore the possible insulinogenic effect of drugs like tianeptine, which enhances rather than inhibits the uptake of 5-HT.
Identification of focal hyperinsulinism in the newborn
For example, the author reported an association between hyperlipoproteinemia and hearing loss in 19732 and, as early as 1981, reviewed 1,400 cases demonstrating an association between hyperlipoproteinemia, hyperinsulinism, and Meniere's disease.
Included in this group are disorders presenting as a predominant hypoglycaemia like glycogenosis, gluconeogenesis defects and hyperinsulinism, the fatty acid oxidation disorders, and the congenital lactic acidaemias (deficiencies of pyruvate carboxylase, pyruvate dehydrogenase, Krebs cycle and mitochondrial respiratory chain disorders).
With insulin resistance, the pancreas produces excessive amounts of insulin (called "hyperinsulinism" or "hyperinsulinemia").
It is thought by many to be exacerbated by hyperinsulinism and elevated growth hormone levels.
Hyperandrogenism, oligomenorrhea, dyslipidemia and hyperinsulinism after precocious pubarche.
Hyperinsulinism reduction associated with icodextrin treatment in continuous ambulatory peritoneal dialysis patients.
Linkage of students with special needs (ie, hypertension, hyperinsulinism, obesity, pregnancy, substance abuse, and psychosocial concerns to community and professional resources).
Other differential diagnosis in childhood includes growth hormone deficiency and hyperinsulinism.
In many of my earlier studies in the 1960's, we showed an "exhaustion" effect with hyperinsulinism, leading into diabetes--which is why I call it diabetogenic hyperinsulinism.
* Hyperinsulinism, which is the excessive production of insulin.