hyperleptinemia

Also found in: Medical.

hyperleptinemia

[‚hī·pər‚lep·tə′nē·mē·ə]

(medicine)

Increased serum leptin level.

References in periodicals archive ?

Thus, obesity is associated with hyperleptinemia and leptin resistance [11].

Adipokines in Semen: Physiopathology and Effects on Spermatozoas

However, in cases of obesity-associated hyperleptinemia, this vasodilatory effect is lost with subsequent development of hypertension.

Adipokines: Potential Therapeutic Targets for Vascular Dysfunction in Type II Diabetes Mellitus and Obesity

The HFD also promoted many indicators that resemble those of human comorbidities caused by obesity, such as hyperinsulinemia, hyperleptinemia, and elevated serum GL, T-Chol, and TG levels.

Classification of different degrees of adiposity in sedentary rats

Thus, it is hard to explain why neurodegeneration is increased in patients suffering from MS, since the condition usually causes hyperleptinemia. This may be partially explained by resistance to this hormone in peripheral tissues, causing augmented secretion of this peptide as well as diminished leptin transport across the BBB [95].

Oxidative stress and metabolic syndrome: cause or consequence of Alzheimer's disease?

Nevertheless, further studies should be conducted in the mare to better understand the response mechanisms to euleptinemia and hyperleptinemia conditions.

Opposing roles of leptin and ghrelin in the equine corpus luteum regulation: an in vitro study

Given that levels of the hormone leptin are normally increased during pregnancy, the authors propose that future research should seek to determine whether BPA directly regulates leptin release from fatty tissue or whether the observed hyperleptinemia is a consequence of the altered metabolic state of these animals.

BPA and insulin resistance: evidence of effects in dams and offspring

Hyperleptinemia rapidly depletes adipocyte fat in lean rats, whereas comparable hyperleptinemia produced by adipocytes in diet-induced obesity does not, implying a leptinergic blockade in adipocytes during overnutrition.

Fat storage in adipocytes requires inactivation of leptin's paracrine activity: implications for treatment of human obesity

Hyperleptinemia is an essential feature of human obesity.

Endocrine regulation of energy metabolism: review of pathobiochemical and clinical chemical aspects of leptin, ghrelin, adiponectin, and resistin

The significance of hyperleptinemia in breast, colorectal, and hepatocellular cancer has been well documented [18], and some studies suggest the role of leptin in thyroid cancerogenesis [11].

Concentrations of Selected Adipokines, Interleukin-6, and Vitamin D in Patients with Papillary Thyroid Carcinoma in Respect to Thyroid Cancer Stages

It has been postulated that, in obesity, neurons located in the ventromedial hypothalamic nucleus that express leptin receptors become desensitized to chronically elevated levels of leptin (hyperleptinemia) suppressing its anorexigenic effects while selectively preserving sympathoexcitation (known as "selective leptin resistance") [57, 58].

Relevance of sympathetic nervous system activation in obesity and metabolic syndrome

Furthermore, dysregulated metabolic parameters such as hyperglycemia, hyperlipidemia, and hyperleptinemia are important contributors and amplifiers of systemic oxidative stress (Figure 3).

Oxidative stress and metabolic pathologies: from an adipocentric point of view

The HFD model is extremely efficient for creating pathophysiological conditions such as hyperleptinemia, peripheral insulin resistance, diabetes mellitus, and obesity that lead to long-term metabolic and energy disorders.

Early detection of metabolic and energy disorders by thermal time series stochastic complexity analysis

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