Moreover, subcutaneous adipocyte size is associated with plasma leptin concentrations independent of total adiposity, suggesting that hyperleptinemia
in obesity is likely a function of both subcutaneous adipocyte hypertrophy and hypersecretion.
2009) phenotype (obesity, hyperleptinemia
, hyperglycemia, hyperinsulinemia, increased insulin/glucose ratio) (Plagemann et al.
of aging explains why diets fail Americans who are eating less calories as they age but still gaining weight.
The variations of leptin receptor gene have been identified and these result in the development of the leptin resistance leading to a state of hyperleptinemia
and obesity .
Induction of obesity and hyperleptinemia
by central glucocorticoid infusion in the rat.
Leptin and hyperleptinemia
from friend to for cardiovascular function.
For instance, if an animal consumes too many energy-laden calories and is inactive, this promotes hyperleptinemia
and fat accumulation in the body (Kalra et al.
High leptin levels have been deemed as a component of the metabolic syndrome, obesity, IR, hypertension and dyslipidemia (58), and hyperleptinemia
may lead to leptin resistance.
In the present study there was no interruption or augmentation of linear growth by either hypoleptinemia or hyperleptinemia
Tumor necrosis factor-alpha contributes to obesity-related hyperleptinemia
by regulating leptin release from adipocytes.
is a hallmark of obesity, and leptin has been shown to stimulate increased levels of tumor necrosis factor-alpha and other cytokines that can increase vascular tone and reduce elasticity.
Pubertal exposures in male mice cause increased body weight gain, hepatic steatosis, hyperinsulinemia, and hyperleptinemia
(Zuo et al.