Leptin receptors are expressed in coronary arteries, and hyperleptinemia
causes significant coronary endothelial dysfunction.
Deranged lipid metabolism, activation of the RAS, and hyperleptinemia
lead to the development of hypertension10.
In rats given a high-fat diet, those exposed to BPA had a greater increase in obesity, dyslipidemia, and hyperglycemia (some of the conditions that define metabolic syndrome in humans), as well as in hyperleptinemia
, hyperinsulinemia, and glucose intolerance, than unexposed rats on the same diet (Wei et al.
directly affects testicular maturation at different sexual stages in mice, and suppressor of cytokine signaling 3 is involved in this process.
Association between hyperleptinemia
and oxidative stress in obese diabetic subjects.
In the same study chronically induced hyperleptinemia
was shown to induce resistance to natriuresis and NO like effects.
The main group was characterized with hyperleptinemia
and increased levels of VEGF and resistin, which correlated with an increase in MAU and a decline in GFR.
Protodioscin ameliorated dyslipidaemia, insulin resistance, hyperleptinemia
and hyperuricaemia in high fructose fed mice
in obese adolescents deregulates neuropeptides during weight loss.
and hypoadiponectinemia have been associated with increased risk of insulin resistance, overweight, and diabetes mellitus in adult patient .
Finally, the diabetic mice we used (db/db) suffer from obesity and hyperleptinemia
, and these factors may have effects on endothelial function independent of diabetes per se.
28) Normal leptin Characteristics values Hyperleptinemia
45 8 Mean age [+ or -] SD (a), years 28 [+ or -] 11 19.