oxaluria

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oxaluria

[‚äk·səl′yu̇r·ē·ə]
(medicine)
The presence of oxalic acid or oxalates in the urine.
References in periodicals archive ?
Allena's lead product candidate, reloxaliase, is a first in class, oral enzyme therapeutic for the treatment of hyperoxaluria, a metabolic disorder characterized by markedly elevated urinary oxalate levels and commonly associated with kidney stones, chronic kidney disease and other serious kidney disorders.
"At Allena, we are committed to providing a first-in-class treatment for the full spectrum of patients with enteric hyperoxaluria," said Louis Brenner, M.D., President and Chief Executive Officer of Allena Pharmaceuticals.
The US Food and Drug Administration (FDA) has granted breakthrough Therapy Designation to United States-based Dicerna Pharmaceuticals' DCR-PHXC intended for the treatment of patients with primary hyperoxaluria (PH) type 1, it was reported yesterday.
Another causes are metabolic factors (hypercalciuria, hyperoxaluria, hyperuricosuria and hypocitraturia) which are common in HSK patients and the coexistence of HSK with medullary sponge kidney (a known cause of high-risk stone disease).
This partnership covers ONPATTRO, approved in the EU in August 2018 for the treatment of hATTR amyloidosis in adults with stage 1 or stage 2 polyneuropathy; givosiran, a late-stage investigational RNAi therapeutic for the treatment of acute hepatic porphyria (AHP); as well as lumasiran, a late-stage investigational RNAi therapeutic for the treatment of Primary Hyperoxaluria Type 1 (PH1).
Francis Food Pantries and Shelters, the Wounded Warrior Project, and the Oxalosis and Hyperoxaluria Foundation.
The woman had two risk factors for hyperoxaluria: gastric bypass surgery (which increases oxalate absorption secondary to fat malabsorption) and prolonged antibiotic therapy three months previously for an abdominal wall abscess (antibiotic therapy can deplete oxalate-degrading bacteria in the intestinal tract).
Nathan was later moved to Birmingham Children's Hospital where he was diagnosed with primary hyperoxaluria - a rare condition which can cause renal failure.
Two copies of the gene cause a disease known as primary hyperoxaluria, which can result in kidney failure in toddlers.
Inherited metabolic disorders causing acrocyanosis also include fucosidosis, hyperoxaluria Type I, congenital disorder of glycosylation and mitochondrial disorders with onset in early infancy and multisystem involvement.
Many factors contribute to CaOx stone formation such as hypercalciuria (resorptive, renal leak, absorptive, and metabolic diseases), hyperuricosuria, hyperoxaluria, hypocitraturia, hypomagnesuria, and hypercystinuria [35].
The subtype Ie is associated with enteric hyperoxaluria and in all these cases clinicians have confirmed inflammatory bowel diseases (IBD) for these patients.