Sise et al., "Both hypoxemia and extreme
hyperoxemia may be detrimental in patients with severe traumatic brain injury," Journal of Neurotrauma, vol.
Hyperoxemia caused by resuscitation with pure oxygen may alter intracellular redox status by increasing oxidized glutathione in asphyxiated newly born infants.
Therefore, we conducted this study to investigate the diagnostic value of pulse oximetry in detecting acidosis, hypercapnia, hypoxemia, and
hyperoxemia.
(24) An increased, extracellular matrix of chorionic villi, produced in excess by villous fibroblasts in response to intravillous hypoxia associated with intervillous
hyperoxemia, (25,26) manifests as intense eosinophilia of villous cores (Figure 1, H).
* Once ROSC is achieved, titrate FiO2 to achieve arterial oxyhemoglobin saturation between 94% and 99% to limit the risk of
hyperoxemia.
We were taught that prevention of prolonged periods of
hyperoxemia could help prevent the development of this condition, which in its worse forms causes permanent loss of vision.
Do
hyperoxemia and hypocapnia add to the risk of brain injury after intrapartum asphyxia?
It's not surprising that breathing oxygen between bouts of high-intensity exercise to induce
hyperoxemia will enhance performance of that exercise [3035].
It is a combined modality treatment with three process steps: WBH, induced hyperglycemia, and
hyperoxemia. It was further developed into a systemic therapy of high efficiency and selectivity, since the knowledge of the synergistic-additive effects of chemotherapy became known.
Furthermore, reduced p[O.sub.2] (hypoxemia) is associated with reduction in AV difference and
hyperoxemia with increased AV difference.(7) There is good theoretical reason to suppose that capillary- and arterial-blood p[O.sub.2] will agree more closely if arterial p[O.sub.2 is reduced than if arterial p[O.sub.2 is normal or raised.
Capillary values for pH and [Pco.sub.2] are usually within 0.05 and 7.5 mmHg (1 kPa) of corresponding arterial values; however, [Po.sub.2] underestimates [P.sub.a][o.sub.2] and, therefore, cannot exclude
hyperoxemia [7].
Purohit and coworkers listed traditional methods to treat pulmonary hypertension to include
hyperoxemia, as oxygen dilates pulmonary vessels and decreases pulmonary vascular resistance, hyperventilation as a standard, effective therapy for persistent fetal circulation with high pulmonary vascular resistance, and the use of tolazoline (Priscoline, an alpha adrenergic blocker) given IV with fluid and volume expanders.