Hyperparathyroidism


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Related to Hyperparathyroidism: hypoparathyroidism, Primary hyperparathyroidism, Secondary hyperparathyroidism

hyperparathyroidism

[‚hī·pər‚par·ə′thī‚rȯid‚iz·əm]
(medicine)
Condition caused by increased functioning of the parathyroid glands.

Hyperparathyroidism

 

a disease caused by excessive production of the hormone of the parathyroid glands, usually occurring as the result of adenoma of those glands.

An excess of parathyroid hormone mobilizes the calcium in the bones, raises its level in the blood and lowers the level of phosphorus, and raises the quantity of calcium and phosphorus in the urine (which is then discharged). Softening and deformation of the bones is the result of this process, making possible spontaneous fracture or fracture caused by minimal injury. Visceropathic forms of hyperparathyroidism are characterized by calcium deposits in the internal organs. The most widespread is the renal form (formation of calculi in the kidneys and urinary tracts). The cause of formation of adenomas in the parathyroid glands is not known. Hyperparathyroidism is more commonly found in women. Treatment involves removal of the tumor; orthopedic treatment is necessary when the disease affects the bones, and removal of the calculi is necessary in nephrolithiasis.

L. M. GOL’BER

References in periodicals archive ?
In 1926, at the Massachusetts General Hospital in Boston, Edward Churchill, assisted by an intern named Oliver Cope, operated for the seventh time on the famous sea captain Charles Martell for severe primary hyperparathyroidism (HPT).
Primary hyperparathyroidism is characterized by both increased levels of PTH and calcium and both of these have been shown to stimulate adrenocortical steroid production in various in vitro and in vivo studies (2-8).
In the case described above, primary hyperparathyroidism was suspected because of his PTH being within the normal range in presence of hypercalcemia as any elevation in serum calcium should suppress the PTH unless the parathyroid glands are autonomous or non-responsive.
No associated variations were identified, and the diagnosis remained persistent primary hyperparathyroidism of unknown etiology.
3) Apart from the biochemical evidence from radioimmunoassay for parathyroid hormone level, one of the most useful clinical clues to the presence of coexisting hyperparathyroidism is the persistence of hypercalcemia after control of the thyrotoxic state.
Hyperparathyroidism, most often the first sign of MEN1 or FMEN1, can usually be detected by blood tests between the ages of 15 and 50.
The study included only cases of primary hyperparathyroidism diagnosed between the return of the 1986 questionnaire and May 31, 2008.
Key topics covered include strategic competitor assessment, market characterization, unmet needs, clinical trial mapping and implications for the hyperparathyroidism therapeutics market.
Transient hypocalcemia occurs after surgery for primary hyperparathyroidism in 15% to 30% of patients (6-8).
Based on these results, the osteolytic FDG avid bone lesions were classified as multiple brown tumours caused by primary hyperparathyroidism.
Primary hyperparathyroidism remains the third most common endocrine disorder, as approximately 1 in 500 women and 1 in 2,000 men are affected.