Clinically, they all had no symptom for hypoparathyroidism, but the assessment showed hypocalcemia, lower iPTH level, and mild hyperphosphaturia
. In contrast, the urinalysis of all the affected members revealed no abnormalities and indicated a normal renal function.
Current studies have shown a positive correlation between diabetes and kidney stones.14,16,19 In conclusion increased urine acidification, hypocitraturia, hyperoxaluria, hyperphosphaturia
and hypercalciuria are among the pathophysiological mechanisms responsible for formation of stones in diabetes.7,14,16
Management of calcium and phosphorous imbalance can be challenging when dealing with hypophosphatemia and hyperphosphaturia
that commonly occur in the early post-transplant period.
Biochemical investigations revealed hypophosphatemia, hyperphosphaturia
, normocalcemia and normocalciuria.
The characteristic biochemical phenotype is hypophosphatemia, hyperphosphaturia
, normal or low serum calcium, increased serum alkaline phosphatase, normal or increased serum PTH, normal serum 25-hydroxyvitamin-D, and low or normal serum 1,25-dihydroxyvitamin-D (9, 10).
First, the homeostatic function of the kidneys is suboptimal in diabetes, because elevated blood glucose concentrations depolarize the brush border membrane for [P.sub.i] reabsorption and lead to lack of intracellular phosphate and hyperphosphaturia
. Second, during hyperglycemic-hyperinsulinemic intervals, high amounts of glucose enter muscle and fat tissues, which are insulin sensitive.
and hypocalcemia in acute lymphoblastic leukemia.
Treem and Stanley concluded that secondary carnitine deficiency in cystic fibrosis may be caused by chronic malnutrition, feeding infants with low-carnitine baby milk, loss of appetite, vomiting due to frequent lower respiratory tract infections, vitamin D deficiency, secondary hyperparathyroidism followed by renal tubule defect with hyperphosphaturia
, aminoaciduria and tubule acidosis .
The clinical onset is often insidious, and the proximal tubular damage caused by the crystals typically manifests with features of Fanconi syndrome, including normoglycemic glycosuria, aminoaciduria, hyperuricosuria, hyperphosphaturia
, and type II renal tubular acidosis.
Another important feature is renal rickets associated with hyperphosphaturia
and hypophosphatemia due to reduced tubular reabsorption of phosphorus.
There is hypophosphatemia, hyperphosphaturia
, and decreased concentrations of 1.25 dihydroxyvitamin D3 concentrations in the plasma.
Hypophosphataemic rickets (HR) is a genetic disorder whereby there is reduced reabsorption of phosphate in renal tubules which in turn leads to chronic hyperphosphaturia
and hypophosphataemia and usually normal or reduced vitamin D3 levels.