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A large granular leukocyte with a highly variable nucleus, consisting of three to five lobes, and cytoplasmic granules which stain with neutral dyes and eosin.



(also called polymorphonuclear neutrophil leukocyte, microphage), a type of white blood cell, or leukocyte, occurring in vertebrates and man. The diameter of a neutrophil ranges from 9 to 12 μ. The cytoplasm of these cells contains granules that attract both basic and acidic dyes, and this is why these leukocytes are called neutrophils.

A neutrophil is classified according to its degree of maturity: a metamyelocyte is a young neutrophil with an unsegmented nucleus, a rod neutrophil has a nucleus in the shape of a curved rod, and segmented, or filamented, neutrophils have segmented nuclei. Neutrophils are phagocytes that are capable of ingesting small foreign particles, including microbes. By elaborating hydrolytic enzymes, neutrophils can lyse dead tissue. Neutrophilia is an abnormal increase in the concentration of neutrophils in the blood. (SeeLEUKOCYTOSIS.)

References in periodicals archive ?
Oil Immersion View of Hypersegmented Neutrophil in Peripheral Smear (Leishman Stain 100 x 10X)
Hypersegmented Neutrophil in Cases and Control Population HSN Cases Control Total Present 67 11 78 Absent 33 89 122 Total 100 100 200
Deficiency of the maturation factors also affects the WBCs which can be detected by the presence of hypersegmented neutrophils in the peripheral smear.
Present study intends to compare the Mean Corpuscular Volume and Hypersegmented neutrophils in 100 alcoholics and 100 non-alcoholics.
To compare Hypersegmented neutrophils in peripheral smear of 100 apparently healthy volunteers with history of alcoholism and compare with non-alcoholics.
Also p value was compared regarding MCV values and Hypersegmented neutrophils between the test group and control group using Mann-Whitney U test and Chi square test with software program (SPSS 17.
In peripheral smear examinations, the presence of macro-ovalocytes with MCV more than 115 fL and hypersegmented neutrophils, along with anisocytosis and poikilocytosis affects a megaloblastic disorder associated with B12 or folate deficiency.