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A large granular leukocyte with a highly variable nucleus, consisting of three to five lobes, and cytoplasmic granules which stain with neutral dyes and eosin.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.



(also called polymorphonuclear neutrophil leukocyte, microphage), a type of white blood cell, or leukocyte, occurring in vertebrates and man. The diameter of a neutrophil ranges from 9 to 12 μ. The cytoplasm of these cells contains granules that attract both basic and acidic dyes, and this is why these leukocytes are called neutrophils.

A neutrophil is classified according to its degree of maturity: a metamyelocyte is a young neutrophil with an unsegmented nucleus, a rod neutrophil has a nucleus in the shape of a curved rod, and segmented, or filamented, neutrophils have segmented nuclei. Neutrophils are phagocytes that are capable of ingesting small foreign particles, including microbes. By elaborating hydrolytic enzymes, neutrophils can lyse dead tissue. Neutrophilia is an abnormal increase in the concentration of neutrophils in the blood. (SeeLEUKOCYTOSIS.)

The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
To compare Hypersegmented neutrophils in peripheral smear of 100 apparently healthy volunteers with history of alcoholism and compare with non-alcoholics.
The data so collected was analysed and statistical analysis of Mean, Median, Mode, Standard deviation, Upper limit values and Lower limit values for MCV values and Hypersegmented neutrophils' values between test group and control group were performed using statistical software program SPSS 17.0 for windows student version.
The critical value is highly significant, hence the presence of hypersegmented neutrophils and patients with alcoholism habit are related.
Hypersegmented neutrophils were observed in 67 (67%) alcohol abuse patients while only 11 (11%) control patients had hypersegmented neutrophils in peripheral smear.
Since alcohol intake can cause deficiency of either of these, alcoholism is strongly associated with incidence of hypersegmented neutrophils.
Hypersegmented neutrophils and high MCV generally occur hand in hand.
In the present study, hypersegmented neutrophils were observed in 67 (67%) alcohol abuse patients while only 11 (11%) control patients had hypersegmented neutrophils in peripheral smear.
We propose exploring further work-up for exclusion of vitamin B12 deficiency as the cause of thrombotic microangiopathy, especially for cases with extremely elevated LDH levels (>2500 IU/L), low reticulocyte counts, mild to moderate thrombocytopenia (>50,000/[micro]L), and/or atypical findings on blood smear such as hypersegmented neutrophils.
Caption: FIGURE 4: Magnified view of hypersegmented neutrophils.