Several researchers have reported that hypocalciuria
is associated with preeclampsia due to derangement in calcium metabolism associated with this condition.
The most typical laboratory test abnormalities include hypokalemia, hypochloremic metabolic alkalosis, hypomagnesemia, hypocalciuria
, and renin-angiotensin-aldosterone system activation.
Because of the patient's hypocalciuria
and the insufficient correction of hypomagnesemia by magnesium supplementation, GS was the most likely diagnosis, pending the genetic testing required to establish the diagnosis (3, 5).
Decreased renal filtration and increased tubular reabsorption may result in hypocalciuria
Other tests of note are serum calcium and 24-hour urinary calcium, which provide an indication of daily calcium intake as well as detection of hypercalciuria and hypocalciuria
The reported conditions include sarcoidosis, (5) a variety of rheumatic diseases, (6-9) lymphangioleiomyomatosis, (10) the Hermansky-Pudlak syndrome (11) neurofibromatosis, (12) and familial hypercalcemic hypocalciuria
Novel mutations of the chloride channel Kb gene in two Japanese patients clinically diagnosed as Bartter syndrome with hypocalciuria
Enhanced passive Ca2+ reabsorption and reduced Mg2+ channel abundance explains thiazide-induced hypocalciuria
Patients with suspected PHP should complete a 24-hour urine collection for calcium and creatinine clearance to distinguish PHP from benign familial hypercalcemic hypocalciuria