PET scanning is useful in cases of neocortical epilepsy, where interictal hypometabolism
corresponds to areas of concern.
Fluorodeoxyglucose positron emission tomography may show cerebellar hypermetabolism in early stages followed by hypometabolism
as cerebellar atrophy develops (4).
In pigeons, restricted feeding or fasting caused high-amplitude diurnal cycles in metabolic rates and body temperatures, primarily resulting from nocturnal hypometabolism
and hypothermia (Rashotte et al.
associated with repetitive blast exposure mild traumatic brain injury in 12 Iraq war Veterans with persistent post-concussive symptoms.
In case 6, global hypometabolism
was performed in PET, and in case 7, decreased Tc-99 uptake in the right frontal interhemispheric region was performed in SPECT.
The SOD-1 model is the most studied ALS mouse model and the results showed clinical efficacy, associated changes in brainstem 1H-MRS metabolites and appeared to target glutamate/glutamine availability and in a separate study rescued the G93A SOD1 brain from hypometabolism
Fronto-temporal dementias are characterised by frontal and/or temporal cortex hypometabolism
, with relative sparing of the parietal cortices and precuneus.
The investigators obtained data on biomarkers of amyloidosis (abnormal amyloid-beta-42 [A-beta-42] in cerebrospinal fluid) and neurodegeneration (hippocampal atrophy on MRI measured with FreeSurfer software, temporo-parietal hypometabolism
measured with 18-fluorodeoxyglucose [18-FDG]-PET, and abnormal tau protein levels in cerebrospinal fluid).
When the researchers did consider body mass, they found that lean patients (defined as having a body mass index less than 25) with SDB did possess several specific and non-specific biomarkers of AD risk (increased P-Tau and T-Tau in CSF, hippocampal atrophy using structural MRI, and glucose hypometabolism
using FDG-PET in several AD-vulnerable regions).
In fronto-temporal dementia (FTD), hypometabolism
is seen more in the frontal cortex, and in dementia with Lewy bodies (DLB), it is seen in the parieto-occipital region.
appears about 10 years before the onset of symptoms.
Fetal Brain Hypometabolism
During Prolonged Hypoxaemia in the Llama.