Increased cardiac output in cirrhosis was described more than 50 years ago and a hyperdynamic, hyporeactive
circulation is today a well-characterised element in the clinical appearance of these patients.
, low sensory registration) and who are slow to respond or have a muted response to sensory experiences of typical intensity; and (c) individuals who are sensory cravers (e.
51] In addition, a higher frequency of the Panx1-400C allele was found in cardiovascular patients with hyperreactive platelets compared to those with hyporeactive
Indeed, Tregs isolated from neutrophil cytosolic factor 1 (Ncf1) deficiency mice with a lower level of ROS were hyporeactive
compared to those from wild type mice .
The test found that hyporeactivity was present in up to 97 per cent of depressed patients who later committed suicide, compared to just 2 per cent of the depressed patients who were not hyporeactive
Specifically, patients with a hyporeactive
hypothalamic-pituitary-adrenal axis are at increased risk for a poor outcome after disc surgery (50).
29) attributed these autonomic changes to the presence of reduced baroreceptor-mediated activation of the sympathetic nervous system and a hyporeactive
sympathetic nervous system.