To diagnose patients with hypertelorism, hypotelorism
or telecanthus we require standard baseline values of above mentioned parameters in a normal Pakistani population.
Fetal MRI showed agenesis of the corpus callosum, ventriculomegaly, hypotelorism
, and bilateral congenital cataracts.
Clinical examination at 5 years of age noted some dysmorphic features such as microcephaly, round face, hypertrichosis, low anterior hairline, sparse hair with abundant hair fall, hypotelorism
, synophrys, small and low-set ears, concave nasal ridge, thick lips, widely spaced teeth, and micrognathia.
In this study interorbital and interlens distances were measured using MRI scan and showed that hypotelorism
(i.e., short interorbital length) may be present in a subgroup of individuals with autism and IQ within the normal lower range .
Patients with cebocephaly have ocular hypotelorism
and a proboscis with a single, blind-ended nostril.
Common clinical features in individuals without obvious findings such as cyclopia, synophthalmia, or a proboscis, include microcephaly (although hydrocephalus can result in macrocephaly), ocular hypotelorism
(which can be severe), flat nasal bridge, single maxillary central incisor, and cleft lip and/or palate.
In most cases of alobar holoprosencephaly, patients have obvious midline facial deformities, such as midfacial clefts, a primitive nasal structure and hypotelorism
. In the most extreme forms there is fusion of the globes and orbits, which results in cyclopia.
and unusual skin folds and creases have recently been described as additional phenotypic features in hereditary neuralgic amyotrophy (HNA).
The physical exam found rounded face, sinophris, ocular hypotelorism
, cebocephaly, single nostril, and micrognathia (Figure 1).