However, the uncertainties in low diagnosis rate, lack of clinical evidence and unfavorable safety profile of OH drugs, and adoption of non-pharmacological treatment options as first line therapy may hamper the growth of orthostatic hypotension
drugs market over the forecast period.
It is unclear whether hypotension
per se,  its definition  or its treatment  are associated with abnormal neurological outcomes.
The rationale of study was to find out if administration of low dose bupivacaine is better in reducing the frequency of hypotension
in spinal anesthesia during cesarean section.
However, by rapidly infusing crystalloid as a co-load, phenylephrine boluses can be administered quickly to correct systolic hypotension
. This may explain why the maximal drop in SBP was less among women in the crystalloid group than those in the colloid group.
It may be due to the magnitude of hypotension
and may be related to the faster response time to vasopressors.
One of the patients in the Group B had hypotension
following spinal anesthesia that did not respond to three successive 1 ml doses of injection mephentermine (6 mg/mL).
Spontaneous intracranial hypotension
. Curr Pain Headache Rep 2001;5:284-291.
Spinal anaesthesia is preferred for caesarean section (CS) because of less risk of foetal complications, maternal gastric aspiration and failed intubation.1 During spinal anaesthesia subarachnoid local anaesthetic injection blocks nerves supplying corresponding structures and dermatomes of body.2 CSpain is of somatic origin due to surgical incision and visceral origin due to exteriorisation of uterus and is transmitted through thoracolumbosacral spinal segments, 4th thoracic vertebra to 5th sacral spine segment (T4-S5).3 So a minimal sensory block level up to T4 is required for CS to avoid patient discomfort.1 Autonomic block level is few segments higher than sensory block and is associated with maternal hypotension
Some studies have been done to prevent hypotension
by applying elastic compression stockings.
Diagnostic criteria for spontaneous spinal CSF leaks and intracranial hypotension
. AJNR Am J Neuroradiol.
Among patients with autonomic dysfunction, 40% to 80% of patients also have postprandial hypotension
. (36) This is commonly defined as a decline in SBP [greater than or equal to]20 mm Hg within 2 hours of consuming a meal or decline of SBP to <90 mm Hg when preprandial SBP is >100 mm Hg.
[USA], July 3 ( ANI ): A study has found that a rapid drop in blood pressure, also known as Orthostatic hypotension
, might lead to an undiagnosed cardiovascular disease.