The PVN is established as a leading hypothalamic center
that controls the cardiovascular system and is involved in the regulation of body fluids [47-49].
Bromocriptine mesylate denotes a novel antidiabetic drug in view of its unique action on hypothalamic centers
. The available clinical data corroborates a moderate clinical efficacy of bromocriptine mesylate when used singly or in combination with other antidiabetic drugs.
De Fronzo discusses the concept of insulin resistance in the brain, and notes that hypothalamic centers
for appetite regulation are dysfunctional in obese subjects.1 This 'cerebral insulin resistance' may lead to increased hepatic glucose production and reduced peripheral glucose uptake.
The hippocampus also provides some inhibitory control of hypothalamic centers
that control the levels of the stress hormone cortisol.
Zinc, being a heavy metal, may also have a similar influence on the hypothalamic centers
in Channa punctatus resulting in yolk depletion.