Bromocriptine mesylate denotes a novel antidiabetic drug in view of its unique action on hypothalamic centers
De Fronzo discusses the concept of insulin resistance in the brain, and notes that hypothalamic centers
for appetite regulation are dysfunctional in obese subjects.
The hippocampus also provides some inhibitory control of hypothalamic centers
that control the levels of the stress hormone cortisol.
Zinc, being a heavy metal, may also have a similar influence on the hypothalamic centers
in Channa punctatus resulting in yolk depletion.
The only recent case report associating nocturnal eating binges with bulimia emphasized the anatomic proximity of the hypothalamic centers
controlling sleep and appetite,(6) presumably postulating some hypothalamic lesion as the single common cause.