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Related to idiosyncrasy: drug idiosyncrasy


Med an abnormal reaction of an individual to specific foods, drugs, or other agents
Collins Discovery Encyclopedia, 1st edition © HarperCollins Publishers 2005
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.



a painful reaction that appears in certain persons to irritants that do not produce similar phenomena in the majority of others. The basis of idiosyncrasy is either a congenital increased sensitivity of the autonomic nervous system to particular irritants or a reaction that arises in the body as a result of the repeated weak action of certain substances that are incapable of stimulating antibody production in the body.

Idiosyncrasy differs from allergy in that it may develop even after the first contact with an intolerable irritant—for instance, simple chemical compounds that do not have the properties of allergens; such food products as fish, roe, crab, milk, eggs, and strawberries; such medications as amidopyrine, antibiotics, and sulfanilamide preparations; the pollens of certain flowers and plants; the odor of various animals; insect poisons; and such physical factors as sunstroke, chill, or trauma.

Soon after contact with the irritant, headache appears in the individual, and his temperature rises, sometimes accompanied by mental agitation, disruption of the function of the organs of digestion (nausea, vomiting, diarrhea) and respiration (dyspnea, coryza), edema of the skin and mucosa, and urticaria. These phenomena, which are caused by disruptions of blood circulation, increased permeability of the vessels, and spasms of the smooth musculature, usually pass quickly, but sometimes may continue for several days. The reaction does not produce insen-sitivity to the repeated action of the agent. Treatment requires avoidance of further contact with the intolerable irritant and lowering the body’s heightened reactivity.


The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.


A peculiarity of constitution that makes an individual react differently from most persons to drugs, diet, treatment, or other situations.
Any special or peculiar characteristic or temperament by which a person differs from other persons.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
The third section (Chapters 16-18) focuses more on the idiosyncrasy credit model, with special attention to issues of conformity and nonconformity.
That's the Latin logistics idiosyncrasy that manufacturers, shippers and others in the industry hope to change.
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Like It Is is no Beautiful Thing: Writer Robert Gray lacks Jonathan Harvey's wit and instinct for idiosyncrasy. But it's studded with good performances--Christopher Hargreaves is terrific in a small role as Craig's perplexed brother--and director Paul Oremland has a feel for the bustle of the commercial music business.
In series based on signature shapes including "diamonds," "scissors," and pinched-parallelogram "geminis"--choice examples of each were on view--Zox explored the painterly issues of the day (a systematic approach, the materiality of medium and support) while maintaining a modest idiosyncrasy. Here, in the provinces of the post-painterly, one makes one's mark by leaving graphite lines visible, by recklessly yanking the masking tape off the canvas, and with a skillful palette.
Yet, far from marginalizing the work, Scarpa's idiosyncrasy continues to inspire architects who, in their own cultures and contexts, are swimming against the tide of homogenized industrial production which has dominated the twentieth century.
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Although the luxury and scale - the largest is Herzog and de Meuron's 20 800sq ft (1914[m.sup.2]) residence/media museum in the Napa Valley, due for completion in 2000 - as well as the programmatic idiosyncrasy of most of the examples disqualify them as models, three modest and more generally applicable projects could be profitably replicated: Michael Bell's 900sq ft (83[m.sup.2]) 'Glass House @2[degrees]', MVRDV's pair of 200[m.sup.2] row houses on an Amsterdam canal, and the 179[m.sup.2] 'Curtain Wall House' in Tokyo, 1993-95, by Shigeru Ban, based on the delightful conceit of a literal curtain, and glazed facades that 'can be opened and closed to alter the view and environmental effects such as light and wind'.
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She slogs through a swamp of race, history, trauma, and desire, which is hard enough, then pirouettes along a tightrope between grotesque stereotype and idiosyncrasy, which is even trickier.